home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Temperature-sensitive People

 
  March, 5 2001 10:35
your information resource in human molecular genetics
 
     
Many environmental factors, such as ultraviolet (UV) light from the sun, can mutate DNA. Normally, cells maintain repair mechanisms to counter mutations. The protein XPD belongs to a complex of proteins that mediates a type of DNA repair (called nucleotide excision repair) that corrects defects induced by UV light. Mutant XPD is the cause of three syndromes involving sensitivity to UV light, one of which is trichothiodystrophy (TTD).

The protein XPD is also required for the transcription of DNA into RNA (transcription is the first step in the production of proteins from genes). Mutations that give rise to TTD disrupt both DNA repair and transcription. Now, Jan Hoeijmakers and colleagues (of Erasmus University, Netherlands) report that some of these mutations inactivate XPD at high temperature, such as that produced by fever (Nature Genetics, Vol. 27, No. 3, 02 Mar 2001). And so people who carry these mutations suddenly lose their hair when fighting off severe infections. The researchers show that this is due to a reduction of XPD-dependent transcription--which affects some genes more than others. They propose that the genes encoding some constituents of hair fibers--called 'keratin-crosslinkers'--fall into this category because they are heavily transcribed in normal mature hair cells. They reckon that at high temperature, the patients' hair fibers are depleted of keratin crosslinkers and thus become brittle enough to break.

CONTACT:

Dr. Jan H.J. Hoeijmakers
Erasmus University
Rotterdam, Netherlands
Telephone: (31) 10 408 7199
Fax: (31) 10 408 9468
E-mail: hoeijmakers@gen.fgg.eur.nl


Dr. Priscilla K. Cooper
Lawrence Berkeley National Laboratory
Berkeley, California, USA
Telephone: +1 (510) 486-7346
Fax: +1 (510) 486-6816
Email: pkcooper@lbl.gov

(C)Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.