home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Early Detection Possible For Glaucoma

 
  March, 5 2001 10:04
your information resource in human molecular genetics
 
     
Glaucoma is the leading cause of irreversible blindness and affects 70 million people worldwide. The disease is characterized by increased intraocular pressure due to reduced outflow of aqueous humor, which eventually damages the optic nerve causing blindness. As many as 50% of glaucoma patients are unaware that they have the disease in the early stages, thus making a reliable diagnostic marker for the condition vital. It now looks as though researchers at Tufts University School of Medicine, Boston, have found the first such marker.

Joel Schuman and colleagues examined the main outflow pathway for aqueous fluid in cadaverous eyes from glaucomatous and normal people. They discovered that a cell adhesion molecule called endothelial leukocyte adhesion molecule-1 (ELAM-1) is overexpressed in the outflow pathway of glaucomatous eyes (Nature Medicine, Vol. 7, No.3, 01 Mar 2001).

Their findings suggest that in the early stages of the disease, damage to the cells lining the outflow pathway triggers production of a molecule called NF-kappa B which in turn stimulates the release of inflammatory cytokines such as interleukin-1 and the expression of ELAM-1.

Stanislav Tomarev from the US National Eye Institute discusses this research and ELAM-1's potential to act as a diagnostic marker for glaucoma in an accompanying News & Views article.

Contact:

Dr. Joel S. Schuman
Vision Research Laboratories
New England Eye Center
Tufts University School of Medicine
Boston, Massachusetts
USA
Tel: Tel: +1 617-636-7950
Fax: +1 617-636-4866
Email: jss@mediaone.net

Dr. Stanislav Tomarev
National Eye Institute
Bethesda, MD
USA
Tel: +1 301-496-8524
Fax: +1 301-496-8760
Email: tomarevs@intra.nei.nih.gov

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.