home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Disruption Of Bicarbonate (HCO3-) Ion Transport Responsible For Cystic Fibrosis?

 
  March, 1 2001 3:28
your information resource in human molecular genetics
 
     
HCO3 TRANSPORT AND CF

In this week's Nature (Vol. 410, No. 6824, 01 March 2001), Shmuel Muallem of the University of Texas Southwestern Medical Center, Dallas, and colleagues report that it is disruption in the transport of bicarbonate (HCO3-) ions, not chloride ions, in the lining of the lungs that may be responsible for causing Cystic Fibrosis (CF).

CF is caused by mutations in a protein called Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) which regulates the flow of negative ions in and out of the epithelial cells of the lung. So far, only the transport of chloride ions (Cl-) had been shown to be affected in patients with CF. Yet Cl- ions seem to have little role to play in causing the symptoms of CF which include the over production of thick mucus in the lungs an recurring bacterial infections.

Muallem and colleagues find that CFTR also plays an important role in the transport of bicarbonate (HCO3-) ions. Along with changes in pH in the cell secretions of CF patients, disrupted transport of HCO3- ions can lead to more viscous mucin and the ability of bacteria to bind to the lining of the lungs.

The researchers conclude that instead of trying to regulate the transport of Cl- ions in CF patients, enhancing the transport of HCO3- ions across cell membranes, or increasing the content of HCO3- in the epithelial cells of the lung may help ameliorate the symptoms of CF.

CONTACT:

Shmuel Muallem
tel +1 214 648 2593
e-mail shmuel.muallem@email.swmed.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.