home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Susceptibility to Heart Attack

 
  February, 18 2009 8:41
your information resource in human molecular genetics
 
     

Genetic variants that predispose to heart attack are reported in five studies published online in Nature Genetics. While the effects of these variants on risk of disease are small, further study should provide new biological insight into the mechanisms underlying coronary artery disease, particularly those involving inflammation and lipids.

Four of the studies present genome-wide association studies for heart attack. Jeanette Erdmann and colleagues identify a new susceptibility locus on chromosome 3, in a gene that is highly expressed in the cardiovascular system and may be involved in cell-cell adhesion.

David-Alexandre Tregouet and colleagues report an association with a cluster of variants spanning three genes on chromosome 6. One of these genes encodes apolipoprotein(a), the main protein component of lipoprotein(a), which is a known risk factor for coronary artery disease. The third report from Toshihiro Tanaka and colleagues shows that a variant in a gene called BRAP is associated with risk of myocardial infarction. BRAP binds to two other proteins that this group previously identified as risk factors, and which may be involved in inflammation.

The Myocardial Infarction Genetics Consortium reports three new risk loci and confirms six previously identified loci. Finally, in the fifth study by Daniel Gudbjartsson and colleagues, the authors carried out a genome-wide association for eosinophil numbers. Eosinophils are white blood cells involved in inflammatory processes. Five loci were identified, one of which was also associated with heart attack in six different populations.

Author contacts:

Jeanette Erdmann (University of Lubeck, Germany)
E-mail: j.erdmann@cardiogenics.eu

David-Alexandre Tregouet (INSERM, Paris, France)
E-mail: david.tregouet@upmc.fr

Daniel Gudbjartsson (deCODE Genetics, Reykjavik, Iceland)
E-mail: daniel.gudbjartsson@decode.is

Toshihiro Tanaka (Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan)
E-mail: toshitan@src.riken.jp

Abstracts available online:
Abstract of Paper 1.
Abstract of Paper 2.
Abstract of Paper 3.
Abstract of Paper 4.
Abstract of Paper 5.

C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.