home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Gene Variant Increases Risk of Essential Tremor

  February, 18 2009 8:28
your information resource in human molecular genetics
The first genetic risk factor for the neurological disease essential tremor has been identified, according to a study published online in Nature Genetics. The work may lead to new approaches for the treatment of the disease.

Essential tremor is a progressive neurological disease characterized by tremor of the arms and hands, which can impair writing, drinking, eating and other everyday activities. Although prevalence estimates vary, some studies suggest that it may occur in as may as 13% of individuals older than 65. Kari Stefansson and colleagues carry out a genome-wide association study of individuals with essential tremor, and report that a variant in the gene LINGO1 increases risk of the disease. LINGO1 is involved in cell-cell interactions in the nervous system, and is also known to regulate neuronal survival. The inhibition of LINGO1 activity has been shown to promote neuronal survival and improved function in animal models of other neurological diseases, and the authors suggest that it may be a promising approach to the treatment of essential tremor.

Author contact:

Kari Stefansson (deCODE Genetics, Reykjavik, Iceland)
E-mail: kstefans@decode.is

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.