Scientists have identified several new genetic variants that affect risk of psoriasis, a common inflammatory disease of the skin and joints, according to three studies published online in Nature Genetics. Xue-Jun Zhang and colleagues carried out a genome-wide association study of Chinese individuals with psoriasis, and report variants within the LCE cluster as protecting against the disease.
A third study by Xavier Estivill and colleagues shows that individuals in whom two of the LCE genes are deleted are at higher risk of psoriasis. They show that LCE proteins are induced in normal skin by disruption of the skin barrier, suggesting that compromised skin barrier function after injury may predispose to psoriasis.
Goncalo Abecasis (University of Michigan, Ann Arbor, MI, USA)
Xue-Jun Zhang (Anhui Medical University, Hefei, Anhui, China)
Xavier Estivill (Centre for Genomic Regulation, Barcelona, Spain)
Abstracts available online:
Paper 1 Abstract.
Paper 2 Abstract.
Paper 3 Abstract.
(C) Nature Genetics press release.
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