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Risk-Reduction Surgery Decisions in High-Risk Women Seen for Genetic Counseling

  February, 14 2006 10:40
your information resource in human molecular genetics
Risk-Reduction Surgery Decisions in High-Risk Women Seen for Genetic Counseling

Journal of Genetic Counseling

(Published online: 30 December 2005)

Jessica A. Ray (1), Lois J. Loescher (1, 2) and Molly Brewer (1)

Author Affiliations:
(1) Arizona Cancer Center, University of Arizona, Tucson, AZ
(2) Arizona Cancer Center, PO Box 245024, Tucson, AZ, 85724-5024

Women at greatest risk for hereditary breast and ovarian cancer may consider prophylactic removal of breasts or ovaries as a risk-reduction measure. This report describes uptake of risk-reduction mastectomy (RRM), risk-reduction oophorectomy (RRO), and related factors in 62 high-risk women who received genetic counseling. Seven (11%) participants underwent RRM and 13 (21%) underwent RRO. Of these women, 37% did not have BRCA testing, suggesting other factors influence decisions to undergo surgery. Women who had indicated (pre-genetic counseling) their intent not to have surgery chose not to have surgery. Information received during genetic counseling that women perceived as being most important for influencing risk-reduction surgery decisions was BRCA test result (positive or negative), followed by discussion of family cancer history. Reasons for indecision about risk-reduction surgery included genetic testing results, concerns about surgery, timing in life, and early menopause. The findings enhance our understanding of information that is helpful to women considering this surgery.

Author Contact:
Lois J. Loescher
Email: loescher@azcc.arizona.edu

(C) Journal of Genetic Counseling

Posted by: Tressie Dalaya

Message posted by: Trevor M. D'Souza

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