home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Using The Human Genome To Design Drugs

  February, 17 2004 10:05
your information resource in human molecular genetics
Chemical genomics involves generating large collections of small molecules and systematically using them to change the way cells in the body function. In the March issue of Nature Genetics, Todd Golub and colleagues report that they have developed this approach into a general strategy for drug design. First, they identified a set of genes that switch on or off when one type of leukemia cells is converted back to being normal cells of the immune system. Using this pattern of gene activity as a guide, they were able to predict correctly which 8 out of 1,739 drugs could promote the appearance of normal characteristics in the leukemia cells. This work does not provide an immediate cure for leukemia, but their discovery does mean that enormous numbers of chemical compounds can now be tested for their biological effects, using a single, largely automated technique.

Author contact:

Todd Golub
MIT, Cambridge, MA, and Harvard Medical School, Boston, MA
Tel: +1 617 632 4903
E-mail: golub@broad.mit.edu or barbara_keane@dfci.harvard.edu (assistant)

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.