Compounds being developed into drugs to treat atherosclerosis and obesity may put patients at risk for colorectal cancer, according to a report in the March issue of Nature Medicine.
Peroxisome proliferator-activated receptor-g (PPAR-g) is a transcription factor that activates genes involved in a number of important pathways in the body. Drugs that enhance the effects of PPAR-g are therefore being considered for use in treating certain diseases. But Raymond Dubois and colleagues found that activating PPAR-d increases the number and size of polyps--precancerous growths--in mice that are genetically predisposed to developing intestinal polyps.
Because larger polyps have a higher chance of progressing to a cancerous state, the authors caution that patients with pre-existing polyps may be at increased risk of developing colorectal cancer if they take drugs that enhance PPAR-g.
Raymond N. Dubois
Vanderbilt University Medical Center
Nashville, TN, USA,
Tel: +1 615 343 0527
Dr Dubois is in Colorado until 1 February, but available on his cellphone on +1 615 243 4747, or via Cynthia Manley (Vanderbilt Media Relations) on +1 615 838 0280
Also available online.
(C) Nature Medicine press release.
Message posted by: Trevor M. D'Souza