RNA interference (RNAi) is a powerful technique for silencing the expression of genes and has been described as the most important scientific advance in recent years. But its potential to treat or prevent disease in live animals has thus far been unproven.
In the March issue of Nature Medicine, Judy Lieberman and her colleagues report for the first time that RNAi can successfully prevent liver injury and death in a mouse model of hepatitis.
The researchers used RNAi to silence Fas, which is implicated in a wide array of liver diseases, including autoimmune, viral and transplant rejection hepatitis. Intravenously injecting inhibitory RNAs against Fas, without the need for a delivery vector or virus, allowed mice to survive in two models of autoimmune hepatitis, the researchers report.
Center for Blood Research
Harvard Medical School
Tel: +1 617 278 3381
Also available online.
(C) Nature Medicine press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking