home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Rat Headache May Yield Migraine Treatment

 
  February, 3 2002 4:02
your information resource in human molecular genetics
 
     
As many as 20% of the general population suffers from migraine headaches. Understanding the changes that take place in neurons in the brain that precipitate migraine is essential to the discovery of new methods of treating this incapacitating form of headache.

The headache of a migraine is often preceded by an aura. This consists of flashing lights or shiny angular shapes that drift slowly across the sufferer's vision. After nearly half a century of research, aura is now believed to be due to a phenomenon in which depression of electrical activity spreads across the surface of the cells in the brain's cortex. This cortical spreading depression (CSD) occurs in all vertebrates but has not been linked to the headache that follows an aura -- until now.

Michael Moskowitz and colleagues at Massachusetts General Hospital used rats to model CSD and found that this process activates the trigeminal nerves leading to inflammation in the pain-sensitive meninges, a situation that equates with the condition of headache (Nature Medicine, Vol. 8, No. 2, p. 136, 01 Feb 02).

Constantino Iadecola of Weill Medical Center at Cornell University, discusses the study in an accompanying News & Views article (p. 110) and considers whether CSD could become a valid therapeutic target for treating migraine and ultimately asks that if CSD triggers aura and leads to headache, what triggers CSD?

Author contact:

Dr. Michael A. Moskowitz
Stroke and Neurovascular Regulation Laboratory
Department of Radiology
Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts
Tel: +1 617 726 8442
Fax: +1 617 726 2547
Email: moskowitz@helix.mgh.harvard.edu

Dr. Constantino Iadecola
University of Minnesota
Department of Neurology and Neuroscience
Center for Clinical and Molecular Neurobiology
Minneapolis, Minnesota, USA
Phone: +1 612 624 1902
Fax: +1 612 625 7950
Email Address: iadec001@tc.umn.edu

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.