home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Gas6 Blockade Stops Fatal Thrombosis

  February, 12 2001 4:35
your information resource in human molecular genetics
When blood clots unnecessarily, the resulting thrombosis can be life threatening. For example, deep vein thrombosis (DVT) is a common but potentially fatal condition that occurs in around 2 million Americans each year. Death occurs when fractions of the clot break off and pass to and block the arteries of the lungs. Drugs that are able to prevent the formation of clots include heparin, warfarin and aspirin.

A report in the February issue of (Nature Medicine Vol. 7, No. 2, 01 Feb 2001) by a team of scientists from the Center for Transgene Technology and Gene Therapy at Flanders Interuniversity Institute for Biotechnology, Belgium, describes a potentially new target for the development of anti-thrombotic drugs.

Peter Carmeliet and colleagues investigated the role of a vitamin K-dependent protein called growth arrest-specific gene 6-product (Gas6). Using a strain of mice lacking the gene for Gas6, they discovered that disabling the Gas6 gene protects mice against fatal blood clotting, but at the same time the mice do not suffer from excessive bleeding. Moreover, because of the ability of Gas6 to amplify the response of platelets to clotting stimuli, antibodies to Gas6 protected mice against fatal blood clotting. Thus, this protein may be the target for new anti-clotting drugs.

Dr. Peter Carmeliet
The Center for Transgene Technology and Gene Therapy
Flanders Interuniversity Institute for Biotechnology
Leuven, Belgium
Tel: +32 1634 5772/4
Fax:+32 1634 5990
Email: peter.carmeliet@med.kuleuven.ac.be

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.