home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Discovery Of Role Of The Enzyme Cpla2 Has Exciting Potential For Asthma Therapy

  February, 9 2001 18:20
your information resource in human molecular genetics
A breath of fresh air for asthma sufferers

Asthma is a serious disease that is affecting an increasing number of children and adults and that is characterized by acute and chronic inflammation of the airway passages. An important area of research is the question of how inflammatory cells are recruited to the airways. One hypothesis is that the enzyme, (cPLA2), is involved in this process. In fact studies, previously published in Nature and Nature Immunology, have implicated this enzyme in the development of other lung syndromes. In the February issue of Nature Immunology (Vol. 2, No. 2, 01 Feb 2001), researchers from Japan and the USA used a guinea pig model of asthma to investigate the role of the enzyme, cPLA2, in the development of the disease. They showed that cPLA2 is responsible for the infiltration of an inflammatory cell, the eosinophil, and also for the subsequent airway hyper-responsiveness. This finding has exciting potential for asthma therapy – it now seems possible that, by targeting the enzyme cPLA2, drugs could be developed that block two major aspects of asthma at once to provide relief for asthma sufferers.

Alan R. Leff
University of Chicago
Department of Medicine
Section of Pulmonary and Critical Care Medicine
Chicago, IL 60637
Tel: +1 773-702-1859
Fax: +1 773-702-9181

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.