Lung cancer cells hijack immune system signalling pathways to stimulate metastasis, a Nature paper suggests. The finding indicates new targets for cancer therapy.
Metastatic lung cancer cells secrete a protein, called versican that activates debris-scavenging macrophages and stimulates bone marrow cells to produce the inflammatory protein TNF-alpha. This enhances metastatic growth, Michael Karin and colleagues report. Components of this signalling pathway could be blocked to slow metastasis spread, the authors suggest.
Michael Karin (University of California, San Diego, CA, USA)
(C) Nature press release.
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