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Gallbladder disease (GBD) is one of the major digestive diseases. Its risk factors include age, sex, obesity, type 2 diabetes, and metabolic syndrome (MS). The prevalence of GBD is high in minority populations, such as Native and Mexican Americans. Using ultrasound-based information on GBD occurrence and a 10-cM gene map, Sobha Puppala et al. performed multipoint variance-components analysis to localize susceptibility loci for GBD. Their research, published online on January 6, 2006 in the American Journal of Human Molecular Genetics presents significant evidence of major genetic determinants of symptomatic GBD on chromosome 1p in Mexican Americans.
Author Contacts: Sobha Puppala
Department of Genetics, Southwest Foundation for Biomedical Research, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Ravindranath Duggirala
Department of Genetics, Southwest Foundation for Biomedical Research, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Abstract available online. (C) American Journal of Human Molecular Genetics. Posted by Tressie Dalaya
Message posted by: Trevor M. D'Souza
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