home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

HIV-1 Infection Explained

 
  January, 31 2006 8:14
your information resource in human molecular genetics
 
     
An insight into the development of AIDS from HIV-1, is reported in the February issue of Nature Cell Biology. Human immunodeficiency virus type 1 (HIV-1) causes AIDS by depleting essential immune cells called T cells in infected individuals, resulting in a compromised immune system.

The T cells are destroyed by HIV viral protein Vpr. This protein regulates a variety of cellular functions, including cell death, immune suppression and inhibition of cell proliferation.

One of the ways Vpr exerts its effects is by binding to a T-cell steroid hormone receptor (GR). David B. Weiner and colleagues from the University of Pennsylvania show that through binding to GR, Vpr keeps a crucial co-activator of gene expression, PARP-1, away from it's target, thus blocking an essential survival pathway Vpr induces binding of PARP-1 to GR, thus preventing PARP-1 from activating expression of essential survival genes. Importantly, when GR is normally activated by its steroid hormone, binding of PARP-1 to GR does not occur, indicating that the association of these two molecules is directly mediated by the viral protein Vpr, during HIV-1 infection. Understanding the molecular mechanism that depletes T cells and consequently affects the immune system may open new avenues for therapeutic intervention against HIV-1.

Author Contact:

David B. Weiner (Dept of Pathology and Lab. Medicine, University of Pennsylvania, PA, USA).
E-mail: dbweiner@mail.med.upenn.edu

Abstract available online.

(C) Nature Cell Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.