The prevalence and distribution of all chromosomal defects in fetuses with increased nuchal translucency thickness were examined, as published in the January 2006 issue of Obstetrics & Gynecology (Vol.107, No.1, pp. 6-10). Assessment of risk for trisomy 21 was carried out by a combination of maternal age and fetal nuchal translucency thickness at 11–13 + 6 weeks. Based on the results, it was concluded that in fetuses with increased nuchal translucency, approximately one half of the chromosomally abnormal group is affected by defects other than trisomy 21, and that the distribution of nuchal translucency is different for each type of chromosomal defect.
Kypros H. Nicolaides, MD
Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital Medical School, London, United Kingdom.
Abstract available online.
(C) Obstetrics & Gynecology.
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