home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Two TCRs Are Better Than One

 
  January, 13 2002 6:47
your information resource in human molecular genetics
 
     
Nature Immunology, 07 Jan 02 (online publication); DOI: 10.1038/ni751

T cells normally bear only one type of T cell receptor (TCR) for antigen on the cell surface but a few can bear two. Having more than one is thought to be detrimental, because the second may cause autoimmune diseases. In the February issue of Nature Immunology, scientists show that these so-called dual TCR cells actually play a beneficial role in the immune system by increasing the ability of T cells to recognize invading microbes.

Charles Janeway and colleagues from Yale University School of Medicine have found that each TCR on dual TCR cells plays a different role. In their mouse model, one of the TCRs allows the T cell to develop and enter the blood stream, whereas the other, nonselected, TCR recognizes foreign matter that the first TCR is not capable of seeing. Thus, dual TCR cells can benefit the immune response by increasing the likelihood that T cells will recognize and eliminate foreign matter from the body. This would explain why dual TCR cells are retained at low frequencies in healthy individuals-the benefit of having such cells around apparently outweighs the potential risk of inducing autoimmune disease.

Author Contact:

Xin He
Yale University
New Haven
CT, USA
Tel: +1 203 436 0031
E-mail: xin.he@yale.edu

Additional Contact:

Alexander Rudensky
University of Washington
Seattle
WA, USA
Tel: +1 206 685 7644
E-mail: aruden@u.washington.edu

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.