home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Rods Reel In Dendritic Cells

 
  January, 13 2002 6:39
your information resource in human molecular genetics
 
     
Dendritic cells are central to the regulation, maturation, and maintenance of the body’s cellular immune response against cancer. Part of their job is to activate cancer-killing T cells by “presenting” tumor-associated antigens on their surface. However, dendritic cells have proved difficult to employ in cancer vaccine therapies because, normally, they have to be isolated from individual patients, loaded with tumor-specific antigens in the laboratory, and then administered back to the same patients. In this issue of Nature Biotechnology (Vol. 20, No. 1, 01 Jan 02), Akira Takashima and colleagues, working in mice, circumvent the need to manipulate dendritic cells outside the body through the use of rod-like implants that, after insertion into the skin, both trap skin dendritic cells and load them with tumor antigens.

They achieved this by implanting two types of rods under the skin of each mouse. The first released a substance called a chemokine, which temporarily “traps” dendritic cells by attracting them to the rod as they migrate from the (skin) epidermis to the lymph nodes. (A chemical was applied to the skin of the mice to trigger migration of the cells.) The second implanted rod released tumor-associated antigens that could be taken up by the trapped dendritic cells.

Mice that had been treated this way and were then inoculated with tumors were protected against tumor growth. Moreover, vaccinating mice that already had tumors significantly inhibited tumor growth. This anti-tumor vaccine approach could prove cost effective in dendritic cell–based cancer immunotherapies.

Contact (Author):

Akira Takashima
Department of Dermatology
University of Texas Southwestern Medical Center
Dallas, TX 75390
Email: atakas@mednet.swmed.edu

(C) Nature Biotechnology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.