home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Key Gene In Apoptosis (Cell-Death) Pathway Discovered

  January, 15 2001 4:10
your information resource in human molecular genetics

Malignant skin cancer cells can resist committing suicide when attacked by chemotherapy. The explanation lies in the discovery, reported in this week’s Nature (Vol. 409, No. 6817, 11 Jan 2001, pp. 207–211; News &Views), that a key gene in the cell-death or ‘apoptosis’ pathway is switched off in this cancer.

Scott W. Lowe of Cold Spring Harbor Laboratory, New York, and colleagues show that, unlike other aggressive, drug-resistant cancers, malignant melanoma cells have mutations not in the p53 gene, but in a gene at a step further on from p53 in the apoptosis pathway.

"But what makes this study doubly interesting," says Peter A. Jones of the University of Southern California, Los Angeles, in an accompanying News and Views article, "is that the inactivated gene — Apaf-1 — is merely switched off, instead of being completely lost or mutated." This suggests that the cell-death pathway could potentially be reactivated in melanomas, making them less dangerous.


Scott W. Lowe
tel +1 516 36 78 406
fax +1 516 3678 454

Peter A. Jones
tel +1 323 865 0816
fax +1 323 865 0102
e-mail jones_p@ccnt.hsc.usc.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.