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GPCR Modulators and Screening Optimization for New Chemotypes Using DNA-Encoded Libraries

  January 24, 2024  
Xtalks, Online

Discover a groundbreaking webinar delving into the dynamic world of G-protein coupled receptors (GPCRs) modulator optimization in drug discovery. Small molecule modulators of GPCRs continue to be a highly productive area of research in drug discovery. Orthosteric and allosteric modalities provide a diverse and complex array of possible cellular responses, each requiring its optimization method.

In this webinar, the featured speakers will discuss components of GPCR modulator optimization including affinity, efficacy, signal bias and kinetics. As understanding of GPCR pharmacology has increased, so have methods to screen for them. The featured speakers will also describe robust methods that have been developed using DNA-encoded library (DEL) technology to screen libraries of >100 billion compounds to identify high-quality, drug-like hits that are completely structurally novel even among hits for GPCR targets that have undergone extensive screening through other technologies.

Join this webinar to gain insights into optimizing GPCR modulators and screening through DEL to better identify high-quality and drug-like hits.

Keywords: Drug Discovery, Genomics, Pharmacovigilance, Pharmacology, GPCR, DNA-Encoded Libraries, DEL Screening
Organized by: Xtalks
Invited Speakers: Anthony Keefe, PhD, Senior Vice President, Alliance Management and Innovation, X-Chem
Johan Bartholomeus, PhD, Senior Principal Scientist, X-Chem
Deadline for Abstracts: 2024-02-13
Registration: Free Registration
E-mail: tristan@xtalks.com
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