Free webinar: understanding the pathways of necroptotic cell death

This webinar will help you understand the link as well as differences between apoptosis and necroptosis. It will also introduce new tools developed to activate effectors of necroptosis. A live Q&A session with attendees will follow the presentation.

Topics:

• Necroptosis is a non-apoptotic from of programmed cell death, which depends on the activity of the kinases RIPK1 and RIPK3

• Apoptosis and necroptosis are functionally linked: enzymes involved in inducing apoptosis, such as caspase-8 and FADD, act to suppress necroptosis

• New tools to directly activate the necroptotic effectors RIPK3 and MLKL

• We find that while RIPK1 activates RIPK3 downstream of receptor signaling by using these tools, it is a key suppressor of RIPK3 activation at steady-state