The Jackson Laboratory, Bar Harbor, Maine
August 5-7, 2007
Sunday, August 5th PM
6:00 - 7:00 Registration 7:00 - 8:00 Welcome/ Mixer 8:00 – 9:00 High throughput screening of botanical compounds with insulin sensitizing properties
William Cefalu, Pennington Biomedical Research Center
Monday, August 6th
Morning Session I - Metabolic Syndrome and Mice - Alan Attie, Chair AM
8:00 –8:30 Welcome to The Jackson Laboratory
Edward Leiter and Richard Woychik, The Jackson Laboratory 8:30 - 9:00 Genetic & Genomic Approaches to Diabetes Gene Discovery in Mice
Alan Attie, University of Wisconsin, Madison 9:00 – 9:30 Finding the right mouse for studying the metabolic syndrome
Karen Svenson., The Jackson Laboratory 9:30 - 10:00 Inbred strain variations in glucose tolerance and resistance to metabolic stress
Clayton Mathews, Rangos Research Center, University of Pittsburgh 10:00 - 10:30 Coffee Break, CC Little Lobby Morning Session II - Genomic Manipulations for Discovery - Yaki Barak, Chair 10:30 – 11:00 Genetics and Systems Biology of Metabolic Disease in Chromosome Substitution Strains
Joseph Nadeau, Case Western Reserve University PM
11:00 - 11:30 Genetic perturbations in segregating populations of mice induce changes in network states that drive disease
Eric Schadt, Merck/Rosetta 11:30 – 12:00 Haplotype mapping of HDL-cholesterol QTLs
Beverly Paigen, The Jackson Laboratory 12:00 – 12:30 Discussion 12:30 - 2:00 Lunch, Roscoe’s Afternoon Session - Genetic Manipulations II - Cliff Rosen, Chair
2:00 – 2:30 Mouse models for studying T2D pathophysiology
Derek Leroith, National Institutes of Health
2:30 - 3:00 Functional genomics of diabetes: RNAi modulation in human stem cell models
John Hambor, Pfizer Global Research and Development 3:00 - 3:30 “Humanizing” the mouse
Leonard Shultz, The Jackson Laboratory 3:30 - 4:00 Coffee Break, CC Little Lobby 4:00 – 4:30 Non-genetic variation in diet-induced obesity in C57BL/6J mice
Leslie Kozak, Pennington Biomedical Research Foundation 4:30 – 5:00 Molecular Genetics of PPARgamma
Yaacov Barak, The Jackson Laboratory 5:00 - 5:30 Discussion Tuesday, August 7th Morning Session - New Mouse Models - Ed Leiter, Chair AM
8:00 – 8:45 Roger Cone Plenary Speaker 8:45 – 9:00 Discussion 9:00 – 9:30 Evaluating NONcNZO10, a new polygenic model of T2D
Cai Li, Merck Research Laboratories 9:30 – 10:00 NONcNZO10/LtJ Mice; A Better Model of Translational Pharmacology for Type 2 Diabetes?
Michael Gibbs, PGRD, Groton Laboratories 10:00 – 10:30 Coffee Break, CC Little Auditorium 10:30 - 11:00 TallyHo mice
Juergen Naggert, The Jackson Laboratory 11:00-11:30 Modeling Alström’s Syndrome in ALMS1 mice
Gayle Collin, The Jackson Laboratory 11:30 – 12:00 New insights into T2D pathophysiology in NZO mice
Hans-Georg Joost, German Institute of Human Nutrition
PM
12:00 – 12:30 Predicting diabetic kidney disease in mouse models
Matthew Breyer. Eli Lilly and Company
12:30 – 1:00 Discussion 1:00 - 2:00 Lunch, Roscoe’s Afternoon Session - Rat Models - Howard Jacob, Chair 2:00 – 2:30 Using rat models to understand T2D pathophysiology
Howard Jacob, Medical College of Wisconsin 2:30 – 3:00 A rat model for the metabolic syndrome and longevity
Charles Burant, University of Michigan 3:00 – 3:30 Using the GK rat to study T2D pathophysiology
Carina Ammala, GlaxoSmithKline 4:00 – 6:30 Harbor Cruise, Departs from Bar Harbor Regency 6:30 Lobster Dinner, Pool House at Bar Harbor Club 9:00 Water Taxi from Pool House to Bar Harbor Regency
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