Welcome to Assay Development & High-throughput Screening

7:55 Opening Remarks Featured Presentations

8:00 How New Technologies Reshaped Modern Drug Discovery: A Fascinating Journey of 20 Years
John Wang, Ph.D., Associate Director, Drug Discovery, CHIRON CORPORATION

8:45 Cell Based Screening: Applications in the Real World
John Morin, Ph.D., Director, High Throughput Screening, WYETH RESEARCH

9:30 Refreshment Break
Session I: Cell Based Assays and HTS Screenings

10:00 Cell-based ELISA for Selection of Humanized Variants Directed against Cell Surface Antigen
Gloria Meng, Ph.D., Assay and Automation Technology, GENENTECH, INC.

10:30 Development of Phagocytosis and Endocytosis Assays using pH-sensing Fluorescent Dye
Anton Beletskii, GE GLOBAL RESEARCH CENTER

11:00 Phenotypic Fingerprinting of the Cell Cycle Using High Content Imaging in Cancer Cell Models
Michele Dowless, Biochemist, Lead Generation Biology , ELI LILLY & CO.

11:30 Development of A Novel Cell-Cell Fusion Assay System and its Use in CCR5 Inhibitor Discovery
Changhua Ji, M.D., Ph.D., ROCHE PALO ALTO

12:00 Lunch Session II: In vitro Assays and Screening

1:30 Investigation of Vesicle Electrokinetic Chromatography as an In Vitro Assay for the Estimation of Intestinal Permeability of Pharmaceutical Drug Candidates
Robert Pascoe, Ph.D., MERCK & CO.

2:00 A High Throughput Affinity-based Screening Technology for Soluble Proteins
Bin Li, Associate Director, Lead Discovery, ANADYS PHARMACEUTICALS

2:30 Use of Culture-free Functional Assays on GPCRs
Vincent Dupriez, Ph.D., Head, Molecular Biology & Assay Design , EUROSCREEN S.A.

3:00 Refreshment Break

3:30 Microfluidics Based Assays to Discover New Phosphatase Inhibitors Scaffolds
Dominique Perrin, Ph.D., Group Leader, Biochemical Pharmacology, SERONO PHARMACEUTICAL RESEARCH INSTITUTE

4:00 High Throughput Functional Genomics for Target Discovery and Compound Profiling
Christian Korherr, Ph.D., Group Leader, Molecular & Cell Biology, XANTOS BIOMEDICINE AG

4:30 Casting a Wider Net: Use of Multiple Screening Approaches to Identify Hits Against Less Tractable Oncology Targets
Peter J. Tummino, Ph.D., MMPD Enzymology & Mechanistic Pharmacology, GlaxoSmithKline Pharmaceuticals

5:00 Oral Presentations from Selected Abstracts
Submit your abstract before May 22, 2006 to be considered

5:30 Networking Reception and Poster Session


Friday, June 23, 2006


7:15 Breakfast
Session III: Applications in Drug Discovery

8:30 Cells are a Drug Discovery’s Best Friend
Paul Lang, Ph.D., Head of cellular Pharmacology, SERONO PHARMACEUTICAL RESEARCH INSTITUTE

9:00 Identification of Positive Allosteric Modulators for the M4 Receptor using a Functional Cell-based Assay in High Throughput Screening
Robert Bostwick, Ph.D., Associate Director, ASTRAZENECA PHARMACEUTICALS

9:30 An Innovative Strategy to Discover and Develop New Anti-infective Agents: Overview and Successful Examples
Gerald Kleymann, UNIVERSITY OF TUBINGEN

10:00 Refreshment Break

10:30 Screening and Identification of HsEg5 Inhibitors for Cancer Therapeutics
Bin Zhang, Ph.D., Group leader and Principle Investigator, ARQULE, INC

11:00 TBD
Mathias Ehrich, SEQUENOM, Inc

11:30 Assessing Assay Agreement in Lead Optimization
Serene Josiah, Ph.D., Partner, Active Drug Design, LLC

12:00 Lunch
Session IV: Data Collection and Management

1:00 Application of High Throughput SNP Genotyping in Drug Discovery
Jun Wang, Ph.D., Human Genetics Department , ROCHE MOLECULAR SYSTEMS

1:30 Advancement of High Throughput Screening Data Collection and Analysis
YingPing Zhang, Sr. Automation Engineer , PFIZER, INC.

2:00 Chemotyping Cellular Networks and Circuits as an Avenue toward Drug Discovery
Daniel Johnson, Ph.D., Senior Scientist, Assay Development, AMPHORA CORPORATION

2:30 Refreshment Break

3:00 High-Throughput SNP Assay Development
Abraham Oommen, Ph.D., Chief Executive Officer, GENESEEK, INC.

3:30 DME Screening in Drug Discovery
Constance Höfer, Consultant, CYPROTEX

4:00 Conference Concludes

YingPing Zhang
Senior Automation Engineer, Pfizer Inc.

Changhua Ji, M.D., Ph.D.
Research Scientist II, Viral Disease Therapy, Roche Palo Alto

Arunan Kaliyaperumal
Senior Scientist, Department of Clinical Immunology, Amgen Inc.

Robert J. Pascoe, Ph.D.
Principal Scientist, RAS-Analytical, Merck & Co. Inc.

Dominique Perrin, Ph.D.
Group Leader, Biochemical Pharmacology, Serono Pharmaceutical Research Institute

Anton Beletskii
GE Global Research Center

John Morin, Ph.D.
Director, High-Throughput Screening, Wyeth Research

Jun Wang, Ph.D.
Principal Scientist, Human Genetics Department, Roche Molecular Systems

John Wang
Associate Director, Drug Lead Discovery, Chiron Corporation

Abraham Oommen, Ph.D.
Chief Executive Officer, GeneSeek AG

Christian Korherr, Ph.D.
Group Leader, Molecular and Cell Biology, Xantos Biomedicine AG

Robert Bostwick, Ph.D.
Assoc. Director & Head, Assay Development and HTS, Lead Generation, AstraZeneca Pharmaceuticals

Vincent Dupriez, Ph D.
Head, Molecular Biology & Assay Design, EUROSCREEN S.A.

Paul Lang, Ph.D.
Head, Cellular Pharmacology, Serono Pharmaceutical Research Institute

Daniel Johnson, Ph.D.
Senior Scientist, Assay Development, Amphora Corporation

Constance Höfer
Consultant, Cyprotex

Gerald Kleymann
University of Tübingen

Gloria Meng, Ph.D.
Assay and Automation Technology, Genentech Inc.

Bin Zhang, Ph.D.
Group leader and Principle Investigator, Dept of Chemical Biology, ArQule Inc.

Bin Li
Associate Director, Lead Discovery, Anadys Pharmaceuticals

Mathias Ehrich
Sequenom, Inc.

Peter J. Tummino, Ph.D.
MMPD Enzymology & Mechanistic Pharmacology, GlaxoSmithKline Pharmaceuticals

Ron L. Johnson, Ph.D.
Team Leader, Molecular Genetic Assay Technologies, Biomolecular Screening and Profiling, NIH Chemical Genomics Center

Serene Josiah, Ph.D.
Consultant, Active Drug Design, LLC

Commercial: $1495.00
Academic/Gov: $695.00
Student: $595.00

Early registration discount

60 days prior to conference start date: 20% discount with pre-payment
30 days prior to conference start date: 10% discount with pre-payment