Dep. Clinical Chemistry, Saarland University Hospitals, Congress Hall Saarbruecken/Germany
14th-16th April 2005
Thursday, 14.04.2005
Session 1: Epidemiology and Clinical Studies (Part 1)
D.S. Wald - Homocysteine and risk of cardiovascular disease and stroke (UK)
L.D. Botto - Improvement in stroke mortality, United States 1990-2001, and its relation to folic acid fortification and other factors (USA)
R. Green - In the post-folic acid fortification era cobalamin deficiency has become the most common modifiable cause of hyperhomocysteinemia: Evidence from a population-based study using holoTC ll and plasma MMA measurements (USA)
W. Herrmann - Response of homocysteine and methionine cycle intermediates to vitamin treatment in dialysis patients (D)
R.S. Vasan - Plasma homocysteine and risk for congestive heart failure (USA)Session 2: Epidemiology and Clinical Studies (Part 2)
C.D. Stehouwer - Hyperhomocysteinemia in diabetes - a double hit? (NL)
O.M. Hess - Effect of homocysteine-lowering therapy on restenosis (CH)
A. de Bree - Homocysteine-lowering interventions and vascular function (NL)
O. Stanger - Findings and implications of homocysteine-modifying treatment in healthy and low risk groups (A)
M. Herrmann - Homocysteine, proBNP and heart insufficiency (D) Session 3: Association of Renal Disease and Hyperhomocysteinemia
M. Tepel - Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure (D)
C. van Guldener - Homocysteine in renal insufficiency: focus on transmethylation (NL)
G. Sunder-Plassmann - Homocysteine and reverse epidemiology in renal disease (A)
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Session 4: DNA-Hypomethylation and Cancer
J. Geisel - Increased homocysteine and SAH concentrations & DNA methylation in vegetarians (D)
I. Tavares de Almeida - Increased HCY and SAH concentrations and DNA hypomethylation in vascular disease (P)
S. Duthie - Colon cancer and genetic variation in folate metabolism: how polymorphisms in the MTHFR gene effects DNA stability and cancer risk (UK)
S. Friso - Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium (I)
Friday, 15.04.2005
Session 5: Pathomechanisms of Hyperhomocysteinemia
H. Jakubowski - Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis (USA)
A. Spijkerman - Hyperhomocysteinemia and S-adenosylmethionine as determinants of vascular structure and function (NL)
D. Fliser - Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans (D)
M. David-Dufilho - Homocysteine induces oxidative stress by uncoupling of no synthase activity through reduction of tetrahydrobiopterin (F)
Session 6: Neurodegenerative Diseases & Cognitive Dysfunction
M.F. Elias - Plasma homocysteine as a risk factor for lowered cognitive performance and Alzheimer's disease (USA)
C.E. Teunissen - Homocysteine: a marker for cognitive performance? A longitudinal follow-up study (NL)
G. Ravaglia - Homocysteine and cognitive function in a healthy elderly community (I)
N.N. Session 7: Association of Hyperhomocysteinemia with Thrombosis & Bone Metabolism
M. den Heijer - Homocysteine, oxidative stress and venous thrombosis. What can epidemiology tell us about pathophysiology? (NL)
I. Martinelli - Hyperhomocysteinemia in cerebral vein thrombosis (I)
J.B. van Meurs - Homocysteine levels and the risk of osteoporotic fracture (NL)
M. Herrmann - Influence of homocysteine on bone metabolism: results from in-vitro and in-vivo studies (D)
Session 8: New Aspects in Hyperhomocysteinemia
E. Nexo - Measurement of holoTC in the assessment of vitamin B12 absorption (DK)
N. Riksen - Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia (NL)
A. Deussen - Adenosine-the missing link to understanding homocysteine pathogenicity or more smoke on the horizon? (D)
P.M. Ueland - Betaine as a determinant of plasma total homocysteine (NO)
K. Pietrzik - New aspects for the periconceptional folic acid supplementation (D)
Saturday, 16.04.2005
Session 9: Hyperhomocysteinemia: Pregnancy Complications, Pre- and Postnatal Development
H.J. Blom - Vitamin B12 insufficiency and the risk of fetal neural tube defects (NL)
B. Fowler - Inborn errors of intracellular vitamin B12 metabolism (CH)
J.M. Scott - Fetal Homocysteine and Birth Weight Are Affected by Maternal Homocysteine before Conception and throughout Pregnancy (UK)
R. Obeid - Markers of folic acid and vitamin B12 status in maternal sera and cord blood (D)
W. Herrmann - Is disturbed homocysteine metabolism a pathogenic factor for preeclampsia? (D)
Session 10: New Methods in the Diagnosis of Hyperhomocysteinemia
T. Teerlink - Measurement of asymetrical dimethylarginine in plasma: Methodical considerations and clinical relevance (NL)
T. Arndt - Total plasma homocysteine measured by liquid chromatography-tandem mass spectrometry with use of 96-well plates (D)
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