Strategic Research Institute, Hyatt at Penn's Landing, Philadelphia, PA
March 8-9, 2004
Monday, March 8, 2004
8:00 - 8:45 - Registration and Breakfast
8:45 - 9:00 - Chairperson's Opening Remarks
9:00 - 9:20 - TECHNOLOGY SHOWCASE CIPHERGEN
Protein Interaction Discovery with SELDI-ProteinChip Technology
9:20 - 9:45 - Networking, Refreshments, and Exhibits
9:45 - 10:00 - Chairperson's Opening Remarks
10:00 - 10:30 - Discovery of Small Molecule Antagonists of Protein Interactions Using Protein SAR Data
10:30 - 11:00 - Design of Small Molecule Inhibitors of Protein-Protein Interactions
Lutz Weber
CSO
morphochem AG
11:00 - 11:30 - What is the Preferred Way for Proteins to Interact?
Ruth Nussinov
Nat’l Cancer Institute
Protein-protein interactions
11:30 - 12:00 - Computational Proteomics: Predicting Protein Function on a Genome-scale
Mark Gerstein, Ph.D.
Molecular Biophysics & Biochemistry Department
Yale University
12:00 - 1:15 - LUNCHEON
1:15 - 1:45 - Controlling Protein-Protein Interactions Using Chemical Dimerizers
Tim Clackson, Ph.D.
Chief Scientific Officer
ARIAD Pharmaceuticals, Inc.
1:45 - 2:15 - Molecular Mechanism of the Crosstalk between Estrogen Receptor and the Src/Ras/Erk Phosphorylation Cascade
2:15 - 2:45 - Structural Approaches Toward Understanding and Inhibiting the Anti-Apoptotic IAP Proteins
Chaohong Sun, Ph.D.
NMR-Based Screeing
Abbott Laboratories
2:45 - 3:15 - Networking, Refreshments, and Exhibits
3:15 - 3:45 - Use Of Active Protein Array (APA) For Identifying Protein-Targeted New Drugs
Neil Sharma, Ph.D.
Hui Ge, Ph.D.
ProteinOne
3:45 - 4:15 - Pathway-based Drug Discovery: Application to TGFb
Luc Selig
Hybrigenics
4:15 - 4:45 - Applications of the BIND Biosensor in Protein Interaction Analysis
Cheryl L. Baird, Ph.D.
Senior Scientist
SRU Biosystems
4:45 - 5:15 - Binding Kinetics of Complex Protein-Protein Interactions Probed by Label-Free SpotMatrix SPR Technology
Rick Baggio, Ph.D.
Research Scientist
Applied Biosystems
5:15 - 6:30 - COCKTAIL RECEPTION
Tuesday, March 9, 2004
7:30 - 8:15 - Registration and Breakfast
8:15 - 8:30 - Chairperson's Recap of Day One
8:30 - 9:15 - Design of Mimics of Alpha-Helices
William F. DeGrado, Ph.D.
Department of Biochemistry and Biophysics
University of Pennsylvania School of Medicine
9:15 - 9:45 - How to Embrace Protein Flexibility in Drug Discovery?
Tomas Lundqvist, P.h.D.
Associate Director at AstraZeneca Structural Chemistry Laboratory
AstraZeneca R&D Mölndal
9:45 - 10:15 - Fragment-Based Drug Discovery Using High-Throughput X-ray Crystallography
Harren Jhoti
Founder & CSO
Astex Technology
10:15 - 10:45 - Networking, Refreshments, and Exhibits
10:45 - 11:15 - DP-4 Inhibitor Program for the Potential Treatment of Diabetes
Keith Wilson, Ph.D.
Syrrx
11:15 - 11:45 - Computational Design of Protein Interactions: Building an Optimal Protein Therapeutic
Bassil Dahiyat, Ph.D.
Chief Scientific Officer
Xencor
11:45 - 12:15 - Cys2-His2 zinc finger DNA binding domains (ZFPs)
Casey Case
Sangamo
12:15 - 1:15 - Luncheon
1:15 - 1:45 - Structural Proteomics of Difficult Targets for Drug Discovery
Duncan McRee
ActiveSight
1:45 - 2:15 - Purification of Membrane Proteins Using Retroviral Vectors
Benjamin Doranz, Ph.D.
Integral Molecular, Inc
2:15 - 2:45 - Interactions of Viral Envelope Glycoproteins with Receptors and Antibodies: Molecular Mechanisms and Biomedical Applications
Dimiter S. Dimitrov
Human Immunovirology and Computational Biology Group
LECB, CCR, NCI-Frederick, NIH
CONFERENCE CONCLUDES
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