Diabetes Mellitus: Molecular Signaling, Genes and Therapeutics

Friday, March 5
7:00 - 8:00 AM Breakfast Alberta/Cascade/Conservatory/New Brunswick
8:00 - 11:00 AM The Adipocyte as an Endocrine Cell: Regulation of Energy Metabolism, Brain, Muscle, Liver and Beta Cells (Joint) Van Horne Ballroom
Jeffrey M. Friedman, Rockefeller University
Leptin and the Neuro Circuit Regulating Weight and Adaptive Response to Starvation
Barbara B. Kahn, Beth Israel Deaconess Medical Center
Regulation of Metabolism and Insulin Sensitivity by Adipocyte - Secreted Molecules
Takashi Kadowaki, University of Tokyo
Adiponectin Receptors: Structure, Function and Signal Transduction Mechanism
Jeffrey S. Flier, Beth Israel Deaconess Medical Center
Title to be Determined
9:20 - 9:40 AM Coffee Break Van Horne Foyer
11:00 AM - 1:00 PM Poster Setup Alberta/Cascade/Conservatory/New Brunswick
1:00 - 10:00 PM Poster Viewing Alberta/Cascade/Conservatory/New Brunswick
4:30 - 5:00 PM Coffee & Snacks Available Van Horne Foyer
5:00 - 7:00 PM Regulated Secretory Pathways in Adipocytes and Beta Cells Van Horne A/B
* Amira Klip, Hospital for Sick Children
Harvey F. Lodish, Whitehead Institute for Biomedical Research
Signaling by Acrp30/Adiponectin
Timothy E. McGraw, Weill Medical College of Cornell University
GLUT4 Trafficking Pathways
Christopher J. Rhodes, Pacific Northwest Research Institute
Regulation of Insulin Exocytosis Beyond Generating Secondary Signals
Short Talk Speaker(s) to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour Alberta/Cascade/Conservatory/New Brunswick
7:30 - 10:00 PM Poster Session 1 Alberta/Cascade/Conservatory/New Brunswick

Saturday, March 6
7:00 - 8:00 AM Breakfast Alberta/Cascade/Conservatory/New Brunswick
8:00 - 11:00 AM Stem Cells and Development of Insulin Responsive Tissues (Joint). Session Sponsored by the Juvenile Diabetes Research Foundation International. Van Horne Ballroom
* Douglas A. Melton, Harvard University
Christopher V.E. Wright, Vanderbilt University
Gene Knockout and Lineage Studies of Pancreas Transcription Factors
Speakers to be Announced,
Short Talk Speaker(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Van Horne Foyer
11:00 AM - 1:00 PM Poster Setup Alberta/Cascade/Conservatory/New Brunswick
1:00 - 10:00 PM Poster Viewing Alberta/Cascade/Conservatory/New Brunswick
4:30 - 5:00 PM Coffee & Snacks Available Van Horne Foyer
5:00 - 7:00 PM Signaling and Secretion Networks Van Horne A/B
* Yoshitomo Oka, Tohoku University Graduate School of Medicine
David Ron, New York University School of Medicine
Stress Signal Integration by Phosphorylated Translation Initiation Factor-2 (elF2)
Morris F. White, Joslin Diabetes Center
Coordinate Regulation by the IRS Proteins
Michael P. Czech, University of Massachusetts Medical School
Morris J. Birnbaum, University of Pennsylvania School of Medicine
7:00 - 8:00 PM Social Hour Alberta/Cascade/Conservatory/New Brunswick
7:30 - 10:00 PM Poster Session 2 Alberta/Cascade/Conservatory/New Brunswick

Sunday, March 7
7:00 - 8:00 AM Breakfast Alberta/Cascade/Conservatory/New Brunswick
8:00 - 11:00 AM Insulin Signaling to GLUT4: Breaking Stories Van Horne A/B
* Jeffrey E. Pessin, SUNY, Stony Brook
Konstantin V. Kandror, Boston University School of Medicine
Biochemical Dissection of the Glut4 Pathway
9:40 - 11:00 AM Panel Discussion: PI3-Kinase-Dependent and -Independent Paths for Insulin-Regulated GLUT4 Translocation? At what steps is it Required? Van Horne A/B
Alan R. Saltiel, University of Michigan Medical School
Jeffrey E. Pessin, SUNY, Stony Brook
Jeremy M. Tavaré, University of Bristol
Yannick Le Marchand-Brustel, INSERM
Amira Klip, Hospital for Sick Children
David C. James, Garvan Institute of Medical Research
Yoshitomo Oka, Tohoku University Graduate School of Medicine
Paul F. Pilch, Boston University School of Medicine
9:20 - 9:40 AM Coffee Break Van Horne Foyer
11:00 AM - 1:00 PM Poster Setup Alberta/Cascade/Conservatory/New Brunswick
1:00 - 10:00 PM Poster Viewing Alberta/Cascade/Conservatory/New Brunswick
4:30 - 5:00 PM Coffee & Snacks Available Van Horne Foyer
5:00 - 7:00 PM Signaling, Nuclear Factors and Glucose Homeostasis (Joint) Van Horne Ballroom
* Richard W. Hanson, Case Western Reserve University School of Medicine
Bruce M. Spiegelman, Harvard Medical School
Regulation of Glucose and Energy Metabolism by PPAR-gamma and Coactivators
Domenico Accili, Columbia University
Forkhead Proteins in Insulin Action
Gary B. Ruvkun, Massachusetts General Hospital
Title to be Determined
Short Talk Speaker(s) to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour Alberta/Cascade/Conservatory/New Brunswick
7:30 - 10:00 PM Poster Session 3 Alberta/Cascade/Conservatory/New Brunswick

Monday, March 8
7:00 - 8:00 AM Breakfast Alberta/Cascade/Conservatory/New Brunswick
8:00 - 11:00 AM Lessons from Expressed Gene and Proteome Databases Van Horne A/B
* Alan D. Attie, University of Wisconsin-Madison
Klaus H. Kaestner, University of Pennsylvania School of Medicine
Functional Genomics of the Beta-Cell: From Libraries to Targets
Silvia Corvera, University of Massachusetts Medical School
Proteomic Analysis of TZD Actions
Speaker to be Announced,
Short Talk Speaker(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Van Horne Foyer
11:00 AM - 1:00 PM Poster Setup Alberta/Cascade/Conservatory/New Brunswick
1:00 - 10:00 PM Poster Viewing Alberta/Cascade/Conservatory/New Brunswick
4:30 - 5:00 PM Coffee & Snacks Available Van Horne Foyer
5:00 - 7:00 PM Diabetes and Obesity Genes (Joint) Van Horne Ballroom
* Masato Kasuga, Kobe University Graduate School of Medicine
C. Ronald Kahn, Joslin Diabetes Center
Insulin versus Diabetes Regulated Gene Expression: A Genetic Analysis
David M. Altshuler, Massachusetts General Hospital
Genomic Approaches to Identifying Genes Influencing Risk of Type 2 Diabetes
Stephen O'Rahilly, University of Cambridge
Human Genetics of Extreme Genotypes
Philippe Froguel, Institut Pasteur de Lille
Genetic Approaches of Diabesity
7:00 - 8:00 PM Social Hour Alberta/Cascade/Conservatory/New Brunswick
7:30 - 10:00 PM Poster Session 4 Alberta/Cascade/Conservatory/New Brunswick

Tuesday, March 9
7:00 - 8:00 AM Breakfast Alberta/Cascade/Conservatory/New Brunswick
8:00 - 11:00 AM Role of Cytokines in Type II Diabetes and Insulin Resistance Van Horne A/B
Steven E. Shoelson, Harvard Medical School
Inflammation in Insulin Resistance: Pathogenic Mediator and Target for Reversal
Gökhan S. Hotamisligil, Harvard School of Public Health
Crossroads between Inflammatory and Metabolic Pathways in Diabetes
Roger J. Davis, University of Massachusetts Medical School
Signal Transduction by Stress-Activated MAP Kinases
Speaker to be Announced,
Short Talk Speaker(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Van Horne Foyer
4:30 - 5:00 PM Coffee & Snacks Available Van Horne Foyer
5:00 - 7:00 PM Metabolic Cross Talk (Joint) Van Horne Ballroom
* Eric Newsholme†, University of Oxford
Gerald I. Shulman, Yale University School of Medicine
Potential Role of Mitochondria in the Pathogenis of Insulin Resistance in Man
Luciano Rossetti, Albert Einstein College of Medicine
Hypothalamic "Lipid Sensing" in Diet-Induced Obestity
Mitchell A. Lazar, University of Pennsylvania
Adipose Modulation of Glucose Homeostesis
Short Talk Speaker(s) to be Chosen from Abstracts,
7:00 - 8:00 PM Social Hour Alberta/New Brunswick/Riverview
8:00 - 11:00 PM Entertainment Alberta/New Brunswick/Riverview

Wednesday, March 10
Departure