G-Protein-Coupled Receptors: Evolving Concepts and Drug Discovery

Wednesday, February 18
7:00 - 8:00 AM Breakfast Bataan
8:00 - 9:00 AM Keynote Address Rio Grande Hall C-D
Robert J. Lefkowitz, Howard Hughes Medical Institute at Duke University Medical Center
A Brief History of Seven Membrane Spanning REceptors
9:00 - 11:00 AM GPCR Structure: Receptor Oligomerization Rio Grande Hall C-D
Michel Bouvier, University of Montreal
Oligomerization of GPCR
Kendall J. Blumer, Washington University Medical School
Yeast GPCR Oligomerization
Susan R. George, University of Toronto
Pharmacologic and Functional Implications of GPCR Hetero-Oligimerization
9:20 - 9:40 AM Coffee Break Bataan
11:00 AM - 1:00 PM Poster Setup Rio Grande Hall A-B
1:00 - 10:00 PM Poster Viewing Rio Grande Hall A-B
4:30 - 5:00 PM Coffee & Snacks Available Bataan
5:00 - 7:00 PM GPCR Interacting Proteins Rio Grande Hall C-D
Stephen M. Lanier, Louisiana State University Health Science Center
AGS Proteins, GPR Motifs and the Signals Processed by Heterotrimeric G Proteins
Thue W. Schwartz, Panum Institute
Molecular Mechanisms of Activation of 7TM Receptors
Marilyn Gist Farquhar, University of California, San Diego
RGS-PX1 Connects Gs to EGF Receptor Trafficking and Down-Regulation: From Cell Biology to Mouse Genetics
7:00 - 8:00 PM Social Hour Rio Grande Hall A-B
7:30 - 10:00 PM Poster Session 1 Rio Grande Hall A-B

Thursday, February 19
7:00 - 8:00 AM Breakfast Bataan
8:00 - 11:00 AM GPCR Trafficking and Regulation Rio Grande Hall C-D
Karin A. Eidne, WA Institute for Medical Research
GnRH and TRH Receptors: Monitoring the Formation of Dynamic Protein Complexes in Living Cells
Mark von Zastrow, University of California San Francisco
Regulation of G Protein-Coupled Receptors by Membrane Trafficking in the Endocytic Pathway
Andrew B. Tobin, University of Leicester
GPCR Phosphorylation Offers a "Flexible" Adaptive Mechanism of Regulation
JoAnn Trejo, University of North Carolina
Regulation of Protease-Activated Receptor-1 Signaling and Trafficking
9:20 - 9:40 AM Coffee Break Bataan
11:00 AM - 1:00 PM Poster Setup Rio Grande Hall A-B
1:00 - 10:00 PM Poster Viewing Rio Grande Hall A-B
4:30 - 5:00 PM Coffee & Snacks Available Bataan
5:00 - 7:00 PM GPCR Signaling Microdomains Rio Grande Hall C-D
Michael P. Lisanti, Albert Einstein College of Medicine
Caveolae/Caveolins and Signal Transductions
Jan E. Schnitzer, Sidney Kimmel Cancer Center
Differential Integration of Signaling and Trafficking in Caveolae and Lipid Rafts by G Proteins and GPCRs
Susan F. Steinberg, Columbia University
Beta-Adrenergic Signaling in Cardiac Membrane Microdomains
7:00 - 8:00 PM Social Hour Rio Grande Hall A-B
7:30 - 10:00 PM Poster Session 2 Rio Grande Hall A-B

Friday, February 20
7:00 - 8:00 AM Breakfast Bataan
8:00 - 11:00 AM GPCRs in Infection and Immunity Rio Grande Hall C-D
Marvin C. Gershengorn, National Institutes of Health
Kaposi's Sarcoma-Associated Herpes Virus GPCR
Marc Parmentier, Universite Libre de Bruxelles
Functional Characterization of New Chemoattractant Receptors
Rob Leurs, Vrije University
Constitutive Signalling of HCMV-Encoded G-Protein Coupled Receptors
Speaker to be Announced,
Short Talk Speaker(s) to be Chosen from Abstracts,
9:20 - 9:40 AM Coffee Break Bataan
11:00 AM - 1:00 PM Poster Setup Rio Grande Hall A-B
1:00 - 10:00 PM Poster Viewing Rio Grande Hall A-B
4:30 - 5:00 PM Coffee & Snacks Available Bataan
5:00 - 7:00 PM Sensory GPCRs Rio Grande Hall C-D
Linda Buck†, Hutchinson Cancer Research Center
Olfactory and Gustatory GPCRs
Krzysztof Palczewski, University of Washington
Rhodopsin Structure and Activation
7:00 - 8:00 PM Social Hour Rio Grande Hall A-B
7:30 - 10:00 PM Poster Session 3 Rio Grande Hall A-B

Saturday, February 21
7:00 - 8:00 AM Breakfast Bataan
8:00 - 11:00 AM New Technologies to Study GPCRs Rio Grande Hall C-D
Brian K. Kobilka, Stanford University
Spectroscopic Approaches to Study Conformational Changes in GPCRs
Olivier Civelli, University of California, Irvine
Unraveling the Identity of Orphan GPCRs
Derek T. Chalmers, Arena Pharmaceuticals, Inc.
Moving from Genes to Screens at GPCRs
Dianne M. Perez, Cleveland Clinic Foundation
DNA Microarrays to Define Novel alpha1-AR Signaling Networks
9:20 - 9:40 AM Coffee Break Bataan
4:30 - 5:00 PM Coffee & Snacks Available Bataan
5:00 - 7:00 PM GPCR Genetic Variants in Human Disease Rio Grande Hall C-D
Stephen B. Liggett, University of Cincinnati
Adrenergic Receptor Polymorphisms: Function and Disease Associations
Mariel Birnbaumer, National Institute of Environmental Health Sciences
V2R Mutations and Water Balance
Stephen J. O'Brien, National Cancer Institute
Complex Multifactorial Gene Discovery in Man
7:00 - 8:00 PM Social Hour Bataan
8:00 - 11:00 PM Entertainment Bataan

Sunday, February 22
Departure