Recherches Scientifiques Luxembourg (RSL), Luxembourg
28 - 31 January 2004
Chromatin structure and gene expression mechanisms as therapeutic targets.
(January 28th - January 31st, 2004)
Wednesday, January 28th, 2004 (Afternoon)
Keynote sesssion:
19h00 - 20h00 : James Darnell (New York, USA) : Transcription Factors as Anti-Cancer TargetsThursday, January 29th, 2004 (Morning)
Session I : Chromatin remodeling complexes : mechanisms and structural considerations
8h30 - 9h00 : Wolfgang Fischle (Charlottesville, USA) : Translating the histone code
9h00 - 9h30 : E Kalkhoven (Leiden, The Netherlands) : Fonctiunal domains of CBP acetyltransferases
9h30 - 10h00 : Ed Seto (Tampa, Florida, USA) : Functional domains of histone deacetylases 10h00 - 11h00 : Coffee break 11h00 - 11h30 : BM Turner (Birmingham, UK) : Cellular memory and the histone code
11h30 - 12h30 : free presentations
Thursday, January 29th, 2004 (Afternoon)
Session II : Chromatin structure in health and disease
16h00 - 16h30 : NB La Thangue (Glasgow, UK) : Chromatin control-a place for E2F and Myc to meet.
16h30 - 17h00 : Paolo Sassone-Corsi (Strasbourg, France) : in human disease
17h30 - 18h00 : F Urnov (Richmond, USA) : Genetic and epigenetic therapies for human disease
18h00 - 19h00 : free presentations
Friday, January 30th, 2004 (Morning)
Session III : DNA methylation and chromatin structure related to pathological variations of gene expression
8h30 - 9h00 : SB Baylin (Baltimore, USA) : Dependence of histone modifications and gene expression on DNA hypermethylationin cancer
9h00 - 9h30 : Moshe Szyf (Montreal, Canada) : Regulation of DNA methylation in human breast cancer.
9h30 - 10h00 : J Wagstaff (Charlottesville, USA) : Prader-Willi and Angelman syndromes: imprinting and chromatin structure
10h00 - 11h00 : Coffee break
11h00 -12h30 : free presentations
Friday, January 30th, 2004 (Afternoon)
Session IV : Histone deacetylase inhibitors
16h00 - 16h30 : TK Kundu (Bangalore, India) : Small molecule modulators of histone acetyltransferase p300
16h30 - 19h00 : free presentations
Saturday, January 31th, 2004 (Morning)
Session V: Histone methyltrasferases
8h30 - 9h00 : Tony Kouzarides (Cambridge, UK) : Histone methylation : dynamic or static?
9h00 - 9h30 : T Jenuwein (Vienna, Austria) : Histone methyltransferases, mamalian heterochromatin and genome stability
9h30 - 10h00 : J Mueller (Heidelberg, Germany) : Transcriptional silencing by Polycomb group proteins in Drosophila 10h00 - 11h00 : Coffee break Session VI : Non coding RNA and Heterochromatin Structure
(Session organizer : Ch. Branlant, Nancy, France)
11h00 - 12h30 : program to be announced
Saturday, January 31th, 2004 (Afternoon)
Session VII: Transcription factors interaction with HATs and HDACs
14h00 - 14h30 : RG Pestell (Washington, UK) : Acetylation of non histone substrates in cellular growth and apopotsis
14h30 - 15h00 : L Di Croce (Milan, Italy) : Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.
15h00 - 15h30 : GA Blobel (Philadelphia, USA) : Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.
15h30 - 16h00 : Guy Haegeman (Ghent, Belgium) : To be annopunced
16h00 - 16h30 : Irfan Rahman (Edinburgh, UK) : Redox modulation of histone acetylation and deacetylation in vitro and in vivo: modulation of NF-kB and proinflammatory/antioxidant genes
16h30 - 17h00 : free presentations
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