PharmCourses Ltd, london
8 October 2014
Under current regulations, residual solvents must be controlled in pharmaceutical excipients and dosage forms. Analytical chemists engaged in this work need to understand the fundamental principles of gas chromatography in order to troubleshoot instrument problems and develop robust and efficient methods. This course is designed to give participants a good grounding in chromatographic theory, as it applies to gas chromatography, and to explain the sample preparation and introduction techniques of most relevance to residual solvent testing. Programme Residual solvents: what are they and where do they come from? Chromatographic theory The GC system · Carrier gas · Flow vs. pressure control · Injectors · Columns · Effect of capillary column diameter and film thickness · Retention gaps and the phase ratio effect · Detectors · FID, ECD and MS Techniques for residual solvent analysis · Headspace sampling (theory & practice) · Solid-phase microextraction (SPME; theory & practice) · USP/Ph. Eur. residual solvent methods · Sample preparation tips & tricks Who should attend? This course is aimed at those new to gas chromatography and those with some experience who would like to understand more about the technique.
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