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CfPA - The Center for Professional Advancement, 90 Minute Accredited Online Training
August 8, 2013 at 11:00 a.m.–12:30 p.m. (ET)
Who Should Attend
Individuals from the cosmetic, pharmaceutical and nutrition industries who are involved in the following areas related to development of skin care formulations will find this training very valuable:
• Formulation Chemists
• Regulatory
• Research and Development
• Business and Strategic Planning
• Marketing and Sales Description
This course will be available On Demand: August 9, 2013
Plant derived essential oils are composed of a variety of low molecular weight, often volatile molecules. They are used in Eastern and ancient medicine as anti-inflammatory, anti-microbial anti-fungal and anti-viral agents. Modern studies have shown some of the compounds elicit antimicrobial effects by disrupting the bacterial wall and breaching compartmentalization, ultimately, reducing bacterial viability. Examples of commonly used anti-microbial essential oils include extracts from oregano, anise, citrus, sage and clove. Due to their relatively low molecular weight and lipophilicity, essential oils penetrate intact skin and act as skin penetration enhancers.
In recent years there has been a growing interest in the use of essential oils as preservatives in cosmetic formulations. While this approach may allow for the reduction or elimination of the use of synthetic preservatives, the biological effects of essential oils should be further evaluated.
Gene expression methods are becoming a routine method in the skin care industry to evaluate the biological effects of topical ingredients and formulations in the skin. Gene expression analysis determines how specific compounds activate or inhibit specific DNA molecules, or genes. The results are quantitative and studies can be conducted using in vitro cell cultures, co-cultures and artificial skin, or in vivo with the analysis of punch biopsies.
In the past few years, several gene expression studies have been published that describe the molecular effects of essential oils. For example, sage essential oil was shown to downregulate NFkB in the inflammation cascade, while eugenol isolated from clove essential oil downregulated genes that are involved in cell cycle and apoptosis. Another study showed an essential oil extracted from green leopard produced a dose dependent decrease in iNOS and COX-2 mRNA expression, cytokines that are involved in inflammation.
This webinar will review the common properties of essential oils; interaction patterns with skin, potential adverse effects and mechanisms studied via gene expression analysis.
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Organized by:
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CfPA - The Center for Professional Advancement |
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Invited Speakers:
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Nava Dayan Ph.D., President, Dr.Nava Dayan LLC
Dr. Nava Dayan is an independent consultant offering a wide range of services for the Pharmaceutical, Cosmetic, Personal Care, Research Entities, Regulatory and Government Agencies and other organizations and institutions that are interested in skin health and science. A skin care and health expert, Dr. Dayan has over 24 years of experience in a variety of skin research and development schemes in the Personal Care, Cosmetics, Pharmaceutical, Medical Devices and Delivery System Industries. Expertise include product innovation, skin biochemistry, development of ingredients and formulations, skin delivery and delivery systems for dermal and transdermal applications, prevention of adverse effects, safety assessment (skin toxicology; in vitro methodologies), claim substantiation via clinical study design, execution and data interpretation.
Dr. Dayan’s major strengths and interests include: skin aging, skin inflammatory disorders, delivery systems for enlargement of therapeutic index, natural ingredients and formulations, skin’s innate immunity and barrier integrity, biochemical paths analysis, gene expression, skin research of toxicological endpoint and their assessment.
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Deadline for Abstracts:
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n/a
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Registration:
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Please click here for registration information.
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E-mail:
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sberg@cfpa.com
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