Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
July 23 - August 12, 2013
The three week course in Computational Cell Biology will incorporate a series of didactic lectures on the mathematics of dynamical systems, computational simulation techniques, cell biology and molecular biology. Practicing theoreticians and experimentalists will rotate in for 1-3 day visits during the course to give lectures and interact with the students. Midway through the course, students will select an area for independent study, and the focus of the last week of the course will largely be on these projects, supplemented by continued visiting lecturers. Fundamentals
-Cell biology (signaling, differentiation, motility, cell cycle,
apoptosis)
-Molecular biology (gene expression, posttranslational modification,
proteolysis)
-Mathematical biology (dynamical systems, phase plane, elementary
bifurcations)
-Computational tools (numerical simulation, software, SBML) Advanced Topics
Sniffers, buzzers, toggles and blinkers
Practical bifurcation theory
Reaction-diffusion-advection
Stochastic modeling
Physical chemistry of aggregation/polymerization
Mechano-chemical dynamics
Sensitivity & robustness
Optimization, parameter estimation Case Studies
calcium signaling
cancer modeling
cardiac modeling
signal transduction networks
gene expression
apoptosis
cell cycle regulation
cytoskeletal dynamics
neural models
intracellular trafficking & molecular motors
cell motility & chemotaxis
mechanics of mitosis & cell division
oscillations & bursting in neurosecretion
fertilization phenomena
development
mitochondrial function
cell differentiation
synthetic gene networks
circadian modeling
computational modeling in drug discovery
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