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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
August 7 - 13 , 2012
Complex diseases are conditions that are influenced by the actions of multiple genes, their interactions with each other and with the environment. This lecture course will consider the difficulties in studying the genetic basis of complex disorders such as diabetes, cardiovascular disease, cancer, Alzheimer's disease, schizophrenia and epilepsy. We will discuss genetic-epidemiologic study designs, including family, twin, case/control and adoption studies, as well as methods for quantifying the strength of the genetic influences on a disease. A major focus will be the identification of specific gene effects using both linkage and association analysis and their variants. We will discuss the efficiency and robustness of different designs for such analysis and how evidence from epidemiologic studies informs both the design and interpretation of molecular genetic studies. Study design and methods for analysis of quantitative risk factors related to complex diseases will be covered as well as hapiotype mapping, SNP tagging, meta-analysis and gene-environment interaction. An overview of high throughput laboratory methods will be given to provide participants with insight into the applications of these techniques. Illustrations will be provided through discussion of results from ongoing studies of a variety complex diseases and related risk factors.
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Organized by:
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Ammar Al-Chalabi, Laura Almasy |
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Invited Speakers:
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Faculty in prior course:
Janet Sinsheimer, David Geffen School of Medicine, UCLA
Ingrid Borecki, Washington University School of Medicine
Ruth Loos, MRC Epidemiology Unit, Addenbrook Hospital, Cambridge UK
Evadnie Rampersaud, University of Miami
Pak Sham, University of Hong Kong
Shaun Purcell, Massachusetts General Hospital
Ben Neale, Massachusetts General Hospital
Paul De Bakker, Brigham and Women's Hospital, Harvard Medical School
Dan Geschwind, UCLA Center for Autism Research
Martin Tobin, University of Leicester Visiting faculty will change from year to year, and the specific topics covered will vary.
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Deadline for Abstracts:
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April 15, 2012
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Registration:
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http://meetings.cshl.edu/course/Default.aspx
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E-mail:
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meetings@cshl.edu
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