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HUM-MOLGEN
-> Events
-> Courses and Workshops |
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February 20, 2011 |
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Pharma Training, Window Conference Venue, London UK
9 & 10 June 2011
Day 1: Pharmacokinetic Principles
Topics
What is PK and why is it important? - Absorption, distribution, metabolism and elimination
- Transporters
- Drug failures
- Therapeutic windows
PK terminology - Clearance, Volume of distribution etc. What are they and what is there importance
PK techniques - Non compartmental Analysis
- Compartmental modelling
- Population pharmacokinetics
- Regulatory environment
- Data interpretation
Day 2: PK in Drug Development
Pre-clinical/clinical interface - What PK data are available, how does this influence the
Clinical PK strategy? - Biomarkers
- Implications for CTA- dose choice and dose escalation in first to man studies, adaptive dosing
Variability in PK - Drug interactions; CYPs and transporters strategies and regulatory guidance; types of interaction competitive vs mechanism based; implications for study design (restrictions healthy volunteers vs patients etc)
- Genetic polymorphisms
- Paediatrics
Biologics - Pharmacokinetics/Pharmacodynamics
- Study Design
- Regulatory Environment
There will also be several "learning in action" workshops during both days where participants will have the opportunity to apply knowledge gained during the lectures. an open forum session will be held where delegates can bring along their own issues for discussion.
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Organized by:
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Pharma Training |
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Invited Speakers:
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Dr Graham Blakey, GBPK Consulting Ltd
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Deadline for Abstracts:
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n/a
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Registration:
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Register on the website or by e-mail
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E-mail:
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judy@pharma-training-courses.com
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