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Genetics of Complex Human Diseases

 
  January 26, 2010  
     
 
Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Banbury Campus
July 6 - 12, 2010


Complex diseases are conditions that are influenced by the actions of multiple genes, their interactions with each other and with the environment. This lecture course will consider the difficulties in studying the genetic basis of complex disorders such as diabetes, cardiovascular disease, cancer, Alzheimer's disease, schizophrenia and epilepsy. We will discuss genetic-epidemiologic study designs, including family, twin, case/control and adoption studies, as well as methods for quantifying the strength of the genetic influences on a disease. A major focus will be the identification of specific gene effects using both linkage and association analysis and their variants. We will discuss the efficiency and robustness of different designs for such analysis and how evidence from epidemiologic studies informs both the design and interpretation of molecular genetic studies. Study design and methods for analysis of quantitative risk factors related to complex diseases will be covered as well as the latest ideas in data reduction such as haplotype mapping and SNP tagging. An overview of high throughput laboratory methods will be given to provide participants with insight into the applications of these techniques. Illustrations will be provided through discussion of results from ongoing studies of a variety complex diseases and related risk factors.
 
 
Organized by: Ammar Al-Chalabi, Laura Almasy
Invited Speakers:

Speakers in the last course included:
Ingrid Borecki, Washington University School of Medicine
Paul de Bakker, Brigham and Women's Hospital
Toby Johnson, University of Lausanne
Marina Kennerson, ANZAC Research Institute
Adrian Krainer, Cold Spring Harbor Laboratory
Eden Martin, University of Miami, Miller School of Medicine
Benjamin Neale, Massachussets General Hospital
Shaun Purcell, Mass General Hospital
Jonathan Sebat, Cold Spring Harbor Laboratory
Pak Chung Sham, University of Hong Kong
Janet Sinsheimer, David Geffen School of Medicine

 
Deadline for Abstracts: Application Deadline is March 15, 2010
 
Registration: http://meetings.cshl.edu/course/courseapp_instr.shtml
E-mail: postyn@cshl.edu
 
   
 
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