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Testing for Cytotoxicity-Compliance with REACH and the 7th amendment

  April 14, 2009  
The Center for Professional Advancement, 90 Minute Accredited Online Training
June 4, 2009 at 11:00 a.m. - 12:30 p.m. (EST)

Who Should Attend
Professionals in the cosmetic and personal care or related industries that work and specialize in the following disciplines, as well as groups or companies that provide services in skin care in the following fields:

  • Research and Development
  • Safety Assessment
  • Formulations Development
  • Regulatory Affairs
  • Product Development

With the unique position of the cosmetic and personal care industry of animal testing ban and emergence of REACH, this course is designed to present key parties involved, with the positions, market leads and sources for information. The core of the course is focused on the understanding of current available methodologies, their scope and limitations. Testing for cytotoxicity of a compound provides a fundamental initial understanding for its potential safety upon exposure to viable cells and tissues. Over the years numerous methods have been developed and validated using a variety of cell lines, markers, quantitative and qualitative analyses. Since organ malfunction or failures are associated with cell death, cytotoxicity testing is also used as an end point for evaluation of eye and skin irritation, and photo-toxicity. An effort is put together by regulatory parties to assess the validity of cytotoxicity as a predictive measure for acute toxicity

Module 1: Definitions:
  • Cytotoxicity
  • When is a compound defined as cytotoxic?
  • Types of cells and cell cultures
  • Relevance to the industry- can cosmetic 
    ingredients be cytotoxic?
  • Consideration in study design

Module 2: Regulatory status:
  • Cytotoxicity as a measure for the
     following end points:
    – Eye and skin irritation 
    – Photo-toxicity
    – Acute toxicity
  • ECVAM’s and ICCVAM positions

Module 3: Suggested models:
  • Neutral red release
  • Red blood cell
  • Fluorescein leakage
  • Silicon/cytosensor microphysiometer

Summary and future direction

Question and Answer Session

Organized by: The Center for Professional Advancement
Invited Speakers: Dr. Nava Dayan, Skin Care Research Expert

Dr. Nava Dayan earned her Ph.D. in Pharmaceutics from the Hebrew University in Jerusalem specializing in skin delivery. She is an Associate Adjunct Professor in the Ernest Mario School of Pharmacy at Rutgers University. During her 20 years of experience she has specialized in a variety of areas related to skin treatment including:
  • The research and understanding of the interaction between topically applied compounds and the skin.
  • Findings in skin biochemistry and especially the upper layer of the skin- the stratum corneum
  • Delivery of active compounds into and through the skin and the development of delivery systems to facilitate transport, improve bio-availability and reduce toxicity
  • Design and development of topically applied formulations
  • Design of clinical studies to substantiate market claims and to assure safety
  • Academic teaching and lecturing
  • Industrial experience in both development of active compounds, delivery systems and finished formulations
  • Skin absorption studies in vivo and in vitro for safety/ efficacy assessment
  • In vitro methodologies for safety assessment of topically applied compounds
Dr. Dayan has received numerous awards of excellence for various papers she has authored. She is the author and coauthor of more then 80 publications. Dr. Dayan is a member of the Dermatopharmaceutics Focus Group, and the Abstract Review Committee for the American Association of Pharmaceutical Scientists (AAPS), and the Consumer Products Group of the International Controlled Release Society (CRS). She is also a member of the US Society of Cosmetic Chemists, and the chair of the Annual Cosmeceuticals Summit Symposium. Dr. Dayan teaches at Rutgers University and is the Director of several public and online courses at the Center for Professional Advancement. 
Deadline for Abstracts: n/a
Registration: Please click here for registration information.
E-mail: salbers@cfpa.com
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