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Lyophilization 101: Principles, Physical Properties and Characterization Techniques

  June 10, 2008  
The Center for Professional Advancement, An Online Training Format
September 16, 2008 at 11:00 a.m. - 12:30 p.m. (EST–New York time)

Who Should Attend
This course is designed for personnel in the pharmaceutical, diagnostic, biomedical engineering and biotechnology industries including:

  • Biochemists/Chemists
  • Chemical Engineers
  • Microbiologists
  • Pharmacists
  • R&D personnel
  • Pilot Plant Operations
  • Production Supervisors
  • QA/QC professionals
  • Managers

This 90-minute accredited online course is designed to provide an introduction to the basic scientific and engineering principles of freeze-drying. In addition, this course will provide insight into characterizing and understanding the thermal properties of the formulation through techniques such as differential scanning calorimetry (DSC) and freeze-dry microscopy. 

By understanding the complete thermal picture of the formulation, the process development scientist will be able to develop optimized, robust lyophilization cycles in a much more efficient manner in addition to being able to troubleshoot and correct problematic cycles and formulations more effectively.

Basic theory 
Basic system components 
Temperature monitoring devices 
Vacuum monitoring devices 

Crystalline, amorphous, and mixed systems
Eutectic melts, glass transitions, and collapse temperatures
Physical loss of structure: collapse and meltback
Examples of failed products

Principles of thermal analysis
Thermal analysis equipment
Freeze-dry microscopy equipment and techniques
Applications of thermal analysis and freeze-dry microscopy for frozen and dried systems

Question and Answer Session

Organized by: The Center for Professional Advancement
Invited Speakers: J. Jeff Schwegman Ph.D., Founder/CEO AB BioTechnologies

J. Jeff Schwegman, Ph.D. is currently the founder and chief executive officer of AB BioTechnologies where he specializes in speaking and consulting in parenteral pre-formulation, formulation, analytical, and lyophilization of both small molecules and large biomolecules. He also holds patents and develops new technologies within the lyophilization field. Dr. Schwegman received his BS in Biochemistry from Indiana University in 1992 and began working at Cook Imaging in Bloomington Indiana, where he gained experience in analytical, formulation and process development. In 1999 he began graduate study in the Department of Industrial and Physical Pharmacy at Purdue University under the direction of Dr. Steve Nail, where his focus of research involved studying changes in the physical structure of biological molecules during lyophilization. Dr. Schwegman received his PhD from Purdue University in 2003, and returned to Bloomington where he worked at Baxter Pharmaceutical Solutions as a Research Scientist in the Pharmaceutical Development group. In November 2005, he left Baxter and formed BioConvergence LLC with 3 other founders which specialized in developing new formulations and manufacturing processes for parenteral products. In February 2008, he left BioConvergence, which has become a successful company, to form AB BioTechnologies. He routinely lectures around the world on formulation, stabilization and process development of lyophilized products. He has also been an active member of AAPS since 2001. 
Deadline for Abstracts: n/a
Registration: Please click here for registration information.
E-mail: salbers@cfpa.com
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