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The Center for Professional Advancement, An Online Training Format
February 26, 2008
Who Should Attend
Skin absorption studies are part of various international regulatory requirements for safety assessment of exposure to chemicals. For topically applied formulations, when the skin is the target of action, assessment of penetration can allow for better product design. In vitro skin absorption studies were shown as a reliable way to evaluate penetration of compounds into and through the skin. The course will be beneficial to professionals in the pharmaceutical and cosmetic industries, especially those who are involved in the following areas: - Skin research and development
- Formulation chemistry
- Toxicology and regulatory affairs
- Technical sales and marketing
Description
This 90-minute course will explain the importance of evaluating skin absorption of compounds from topically applied formulations for safety assessment, mechanistic studies and prior to conducting clinical studies.
Module 1:
Rationale for assessment of skin penetration Regulatory parties involved:
– OECD
– CTFA
– WHO Description of general procedure
Module 2:
Preliminary required physical chemical properties Types of diffusion cells Finite and infinite dosing Importance of vehicle applied Fick’s first law for simple diffusion
Module 3:
Skin preparation:
– Choice of skin
– Species differences
– Preparation of tissue samples:
– Full thickness skin
– Epidermal skin
– Stratum corneum
Testing skin barrier integrity Application of test compound Receptor fluid Evaluation of results Summary
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Organized by:
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The Center for Professional Advancement |
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Invited Speakers:
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Nava Dayan, Ph.D.,; Skin Care Research Expert
Dr. Nava Dayan earned her Ph.D. in Pharmaceutics from the Hebrew University in Jerusalem specializing in skin delivery. During her 20 years of experience, she has specialized in a variety of areas related to skin treatment. - The Research and understanding of the interaction between topically applied compounds and the skin
- Findings in skin biochemistry, and especially the upper layer of the skin- the stratum corneum
- Delivery of active compounds into and through the skin and the development of delivery systems to facilitated transport, improve bio-availability and reduce toxicity
- Design and development of topically applied formulations
- Design of clinical studies to substantiate market claims and to assure safety
- Academic teaching and lecturing
- Industrial experience in both development of active compounds, delivery systems and finished formulations
Dr. Dayan has received numerous awards of excellence for various papers she has authored. She is the author and coauthor of more than 80 publications. Dr. Dayan is a member of the Dermatopharmaceuticals Group and abstract review committee for the American Association of Pharmaceutical Scientists (AAPS), and a member of the Consumer Products Group of the International Controlled Release Society (CRS). She is also a member of the US Society of Cosmetic Chemists, and the chair of the Annual Cosmeceuticals Summit Symposium. Dr. Dayan teaches at Rutgers University, and is the Director of the CfPA courses “In Vitro Testing Methodologies for Safety Assessment of Cosmetic Ingredients”,“Pathways for Skin Penetration”, and “Introduction for Skin Aging”.
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Deadline for Abstracts:
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n/a
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Registration:
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Please click here for registration information.
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E-mail:
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info@cfpa.com
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