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Cold Spring Harbor Laboratory, Cold Spring Harbor, New York USA
July 7 - 13, 2008
Complex diseases are conditions that are influenced by the actions of multiple genes, their interactions with each other and with the environment. This lecture course will consider the difficulties in studying the genetic basis of complex disorders such as diabetes, cardiovascular disease, cancer, Alzheimer's disease, schizophrenia and epilepsy. We will discuss genetic-epidemiologic study designs, including family, twin, case/control and adoption studies, as well as methods for quantifying the strength of the genetic influences on a disease. A major focus will be the identification of specific gene effects using both linkage and association analysis and their variants. We will discuss the efficiency and robustness of different designs for such analysis and how evidence from epidemiologic studies informs both the design and interpretation of molecular genetic studies. Study design and methods for analysis of quantitative risk factors related to complex diseases will be covered as well as the latest ideas in data reduction such as haplotype mapping and SNP tagging. An overview of high throughput laboratory methods will be given to provide participants with insight into the applications of these techniques. Illustrations will be provided through discussion of results from ongoing studies of a variety complex diseases and related risk factors.
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Organized by:
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Ammar Al-Chalabi & Laura Almasy |
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Invited Speakers:
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Speakers in the last course included:
Paul de Bakker, Massachusetts General Hospital
Michael Hauser, Duke University Medical Center
Toby Johnson, University of Edinburgh, UK
Cathryn Lewis, Kings College London, UK
Eden Martin, Duke University
Shaun Purcell, Mass General Hospital
Jonathan Sebat, Cold Spring Harbor Laboratory
Pak Chung Sham, University of Hong Kong, China
Janet Sinsheimer, David Geffen School of Medicine
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Deadline for Abstracts:
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March 15, 2008
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Registration:
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How to apply
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E-mail:
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meetings@cshl.edu
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