Physiological Approaches to Ion Channel Biology
	Cold Spring Harbor Laboratory , Cold Spring Harbor, NY June 7 - 27, 2000
	This intensive laboratory/lecture course will introduce students to electrophysiological approaches for the study of ion channels in their native environments. Hands-on exercises will include patch clamp recording of ion channel activity in acutely isolated or cultured cells or neurons in brain slice preparations. Different recording configurations (e.g., whole-cell, nucleated-patch, perforated whole-cell, single channel) will be used. The advantages and disadvantages of each method and preparation will be considered in order to match experimental approaches to scientific questions. Similarly, various methods for ligand/drug application will be demonstrated. A primary goal will be to identify properties of ion channels that allow neurons and non-neuronal cells to carry out their unique physiological or systems-level roles. These properties will be related to information previously gained from molecular cloning and heterologous expression of ion channel genes. Areas of particular interest include channels that (1) are activated by neurotransmitter at central and peripheral synapses, (2) interact with other channels to shape the response properties of neurons, (3) respond to neuromodulators with changes in functional properties, or (4) are developmentally required and regulated. The research interests of guest lecturers will complement and expand this list. This course is intended for students with specific plans to apply these techniques to a defined problem, and students are encouraged to bring their preparation to the course for preliminary studies.
	Organized by:	Angeles B. Ribera, Laurence O. Trussell & Thomas S. Otis
	Invited Speakers:
	Deadline for Abstracts:	Application Deadline: March 15, 2000
	Registration:	Application Deadline: March 15, 2000 apply online
	Email for Requests and Registration:	meetings@.cshl.org
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