Introduction to Molecular Pharmacology
	Oxford University , Oxford, UK 27-28 March 2000
	Molecular Mechanisms Of Cell Signalling · Receptors · G-proteins · Second Messengers · Protein Kinases · Intracellular Phosphorylation Cascades · Allosteric Activation of Target Proteins Signalling Mechanisms In The Nervous System · Neurotransmitters · Receptors · Ion channels · Agonists and Antagonists Case studies of molecular pharmacological intervention in the nervous system Dopamine Neurotransmission And Parkinsons Disease · The neuroanatomy of dopamine pathways · Neuronal cell death in the basal ganglia · Reinforcing Dopamine neurotransmission The Biochemistry And Molecular Pharmacology Of Schizophrenia · Monoamine neurotransmitters and neurological disease · Receptors and neurotransmitter processing enzymes · Pharmacological agents that effect neurotransmitter processing The Biochemistry And Molecular Pharmacology Of Depression And Mania · Monoamine neurotransmitters and neurological disease · Pharmacological agents that influence neurotransmitter levels Introduction To The Molecular Pharmacology Of Cancer Cell Signalling Proteins And Cancer · The mutational evolution of the cancer cell · Oncogenes and Proto-oncogenes · Signalling proteins encoded by oncogenes · Mutant oncogenes that produce hyper-active signalling proteins Case studies in the molecular pharmacology of cancer Enzymes As Targets For Drug Intervention · Disabling a hyper-active Ras oncoprotein Receptors As Targets For Drug Intervention: Tamoxifen And Breast Cancer · Steroid hormone signalling mechanisms · Disabling a receptor protein Introduction To The Molecular Pharmacology Of The Cardiovascular System Cardiovascular Disease · Cholesterol and the build up of atherosclerotic plaque · The conflict that arises between lipid metabolism and the blood clotting reaction · intravascular blood clots leading to heart attacks and stroke. Case studies of molecular pharmacological intervention in the cardiovascular system Long Term Control Of Atherosclerotic Plaque Build Up By The Inhibition Of A Key Enzyme In Lipid Metabolism · Cholesterol transport in lipoprotein particles · Receptors that remove lipoprotein particles from the blood · HMG CoA Reductase, cholesterol biosynthesis and enhancing receptor function · Additional therapy provided by aspirin as an inhibitor of platelet aggregation Short term therapy for acute incidence of heart attack or stroke · Dissolving intravascular blood clots with thrombolytic agents produced by recombinant DNA technology: streptokinase and tPA
	Organized by:	Oxford University
	Invited Speakers:	Dr David Dressler is a molecular biologist who's research contributions lie in the fields of DNA Replication and Recombination, and Alzheimers Disease. He comes to Oxford after twenty five years on the faculty of Harvard College and Harvard Medical School. In addition to research papers and review articles, he has written a volume for the Scientific American Library, entitled Discovering Enzymes. Dr Dressler's appointment at the University of Oxford is in the Department of Biochemistry and a member of Balliol College.
	Deadline for Abstracts:	N/A
	Registration:	Course fees include all daytime refreshments and lunches throughout the course, as well as a drinks Reception on the first evening. Full Fee: five hundred and ninety five pounds sterling Group Discount: five hundred and thirty five pounds sterling - for more than one registration from an organisation (not available with other discounts) Academic Discount: three hundred and fifty seven pounds sterling - for full time members of academic institutions.
	Email for Requests and Registration:	cpdbio@conted.ox.ac.uk
	Posted by: Suzy Hodge   Host: 163.1.204.54 date: November 08, 1999 16:15:44 Generated by meetings and positions 2.0 by Kai Garlipp Logo and Logo Images by Art for BioMed / Syrinx GmbH - Frankfurt / Germany. 4.1 (c) 1995-99 HUM-MOLGEN. All rights reserved. Liability and Copyright.