Infection and Immunity
	Oxford University , Oxford, UK 23-24 February 2000
	Emerging and reemerging infections: the epidemiology of the challenge · Recent trends in infectious disease · Socioeconomic factors · Changes in medical practice · Drug resistance · Extrapolations, prognostications · Climate change · Old friends, new enemies Viral enzymes as drug targets · Principles of selective toxicity as applied to viruses · Classes of viral enzymes · Nucleic acid polymerases and their inhibitors · Proteases and their inhibitors · Glycosidases and their inhibitors · Other enzymes as potential targets Breaking and entering: interactions between pathogens and their cellular receptors · Virus attachment proteins and cellular receptors (e.g. HIV, flu, Dengue) · Specificity, affinity and kinetics · Cellular attachment and invasion by bacteria (*e.g. Salmonella,Mycobacterium, Listeria) · Pathogens as cat burglars · Installing better security Drug resistance: the Red Queen's challenge · The beta-lactam paradigm: a constant battle · The biochemical basis for resistance · The power of selection · Cross-resistance and compensating susceptibility · A battle won, the war to be decided: the story of HIV New approaches to antibiotic discovery · Basic principles of antibiotic action - selective toxicity · Finding new targets for antibiotics to work on? · High throughput screening · "Gene-to-Screen" vs. "Active-to-Target" approaches · Lead compound optimization Effector mechanisms in immunity to pathogens · Kinetics and quality of immune responses (Strep vs Mycobactrium; Flu vs HIV) · Non-adaptive immunity (neutrophils, macrophages, NK cells) · Humoral vs Cellular immunity: antigen recognition · Neutralization and opsonization by antibody · Cytolysis by killer T cells (defence and immunopathogenesis) · Cytokine-mediated effects (helper cells, macrophages) Variation in host susceptibility · Evidence for host variation in immune response factors · Molecular genetics and the hunt for susceptibility genes · MHC association in malaria and dengue infections · Molecular basis for immune response variation · Receptor polymorphisms · Polymorphisms in post-entry factors New approaches to vaccine design · How have we developed most of our current vaccines? · So why don’t we have a vaccine for HIV? · What are the particular problems of developing a vaccine for HIV? · How are these challenges being overcome? Working smarter: combinatorial and evolutionary approaches to the discovery of antimicrobials · Combinatorial chemistry · SELEX · Phage-display · The future
	Organized by:	Oxford University
	Invited Speakers:	Dr William James - Sir William Dunn School of Pathology, University of Oxford Prof Jeff Errington - Sir William Dunn School of Pathology, University of Oxford Dr Sarah Rowland-Jones - Christ Church College, University of Oxford Dr E Holmes - Dept. Of Public Health and Primary Health Care, Institute of Health Sciences, University of Oxford
	Deadline for Abstracts:	N/A
	Registration:	Full Fee: five hundred and forty five pounds sterling Group Discount: four hundred and ninety pounds sterling - for more than one registration from an organisation (not available with other discounts) Academic Discount: three hundred and twenty seven pounds sterling - for full time members of academic institutions.
	Email for Requests and Registration:	cpdbio@conted.ox.ac.uk
	Posted by: Suzy Hodge   Host: 163.1.204.54 date: November 08, 1999 15:43:22 Generated by meetings and positions 2.0 by Kai Garlipp Logo and Logo Images by Art for BioMed / Syrinx GmbH - Frankfurt / Germany. 4.1 (c) 1995-99 HUM-MOLGEN. All rights reserved. Liability and Copyright.