European School in Molecular Medicine and Genetic Epidemiology Module in Statistical Genetics
	Istituto Universitario di Studi Superiori , University of Pavia, Italy November 1999 - September 2000
	Principles of Human Molecular Genetics and Population Genetics Human genome organization, structure and expression of human genes. Human gene mapping by physical and genetic methods; tools and strategies for gene identification in inherited diseases; molecular basis of cancer development. Polymorphisms: allelic frequencies and DNA sequences; penetrance; Hardy-Weinberg equilibrium, linkage equilibrium, inbreeding; kinship; genetic drift; gene flow, natural selection. Statistics Principle of study design in epidemiological and experimental studies, classical inference, criticism of misuse of statistical procedures. Regression models, interaction, model choice, survival analysis, case control studies analysis. Bayesian inference. Linkage and Association Analysis - Part I General likelihood theory, theoretical and practical aspects of parametric, non parametric linkage analysis. Simulation studies for power calculation. Linkage and Association Analysis - Part II Theoretical and practical aspects of parametric, non parametric multipoint linkage analysis, genome screening. Linkage disequilibrium mapping. Shared segment analysis and the BRIC story, quantifying shared haplotypes: introducing the ancestral haplotype reconstruction (AHR) method. Multilocus statistics: the Terwillinger approach. Linkage and Association Analysis - Part III Theoretical and practical aspects of basic and complex association analysis: case control studies, haplotype relative risk, transmission disequilibrium test. Quantitative trait analysis. Regression based methods, non-parametric methods, variance components approach. Computational methods Introduction to Monte Carlo Methods Monte Carlo Methods methods for analysing pedegree of discrete and quantitative traits. Advanced methods in Population Genetics Coalescent theory: chromosomal genealogies under various scenarios such as stratification, migration, variable population size, selection, and recombination. The effects of mutation. Haplotype sharing and linkage disequilibrium mapping. Markov chain Monte Carlo methods for estimation and historical inference.
	Organized by:	Luisa Bernardinelli
	Invited Speakers:	LUISA BERNARDINELLI Dip. Scienze Sanitarie Applicate, Università di Pavia, Italy MARIO COMELLI Dip. Scienze Sanitarie Applicate, Università di Pavia, Italy HYWEL B. JONES Dept of genetics, School of Medicine, Stanford University, Stanford CA , USA and MRC Biostatistics Unit, Institute of Public Healt, University Of Cambridge, UK CRISTINA MONTOMOLI Dip. Scienze Sanitarie Applicate, Università di Pavia, Italy BERTRAM MULLER-MYHSOK Dept. of Molecular Medicine, B. Nocht Inst. for Tropical Medicine, Hamburg, Germany GUGLIELMINA NADIA RANZANI Dip. Genetica e Microbiologia, Università di Pavia, Italy SIMON TAVARE' Program in Molecular Biology and Department of Mathematics, University of Southern California, Los Angeles, CA 90089-1113, USA. ELISABETH THOMPSON Department of Statistics University of Washington, Seattle, WA, USA. LAURA A. ZONTA Dip. Genetica e Microbiologia Università di Pavia, Italy.
	Deadline for Abstracts:	1 September 1999
	Registration:	SELECTION OF APPLICANTS Graduates in Medicine, Dentistry, Veterinary Medicine, Mathematics, Physics and Informatics, as well as in disciplines related to clinical medicine and public health, such as Health Sciences, Nutrition, Biology, Pharmacy, Social Sciences, are encouraged to apply. A good mastery of basics genetics, probability and statistics is not a prerequisite for acceptance but it will be a great advantage. A good command of English is a prerequisite for acceptance. A total of 20 students will be admitted. The selection of candidates will be based on the curriculum vitae. FELLOWSHIPS A limited number of fellowships for the programmes are available. Candidates who wish to become eligible for a fellowship should specifically state so in their letter of application. These fellowships will cover (a part of) the admission fee or accommodation. APPLICATIONS AND FEES The course is open to students of any nationality. The deadline for receipt of applications is 1 September 1999, and applicants, whether successful or unsuccessful, will be informed by 15 September 1999. The admission fee is 6,000,000 Italian Lira (3000 EURO).
	Email for Requests and Registration:	gcarla@nick.unipv.it
	Posted by: Luisa Bernardinelli   Host: baby.unipv.it date: June 04, 1999 8:36:13 Generated by meetings and positions 2.0 by Kai Garlipp Logo and Logo Images by Art for BioMed / Syrinx GmbH - Frankfurt / Germany. 4.1 (c) 1995-99 HUM-MOLGEN. All rights reserved. Liability and Copyright.