Molecular Biology and Genetic Engineering
	University of Oxford , Oxford, England 11 - 14 October 1999
	About the Course Our ability to isolate genes, analyse or alter them and return them to a suitable host has revolutionised all areas of biology and medicine. This course is designed to give all participants a good basic grounding in the concepts and applications of genetic engineering and to allow them to interact more effectively and productively with those who use this technology in research and development. The course is tailored to meet the needs of those who have had little exposure to the ideas or practice of genetic engineering. The course begins with an introduction to the tools of genetic engineering which provides a thorough grounding in the fundamental principles of handling and manipulating DNA in bacteria and complex organisms. These ideas are developed to show how the techniques of genetic engineering can be applied to produce recombinant proteins in bacteria. The course then examines the genes and patterns of gene expression in a variety of complex organisms including yeasts, plants, insects and mammals. The techniques for isolating genes from complex organisms and the subsequent engineering of these genes are discussed, with an emphasis on how engineered genes may be used to create transgenic animals and plants or to produce recombinant proteins in cell factories. Participants may attend the whole course or book for Part I or II only. A 10% discount is given on the course fee for those registering for both Part I and Part II. Who Should Attend? The course is designed for managers and scientists at all levels in R&D, in both private and public sectors, and for others (such as patent lawyers, business analysts, biotechnology marketing managers, venture capitalists) who want to know about genetic engineering. No knowledge of molecular biology is assumed although a basic background in biology would be an advantage PART I (I ½ days) Genetic Engineering and Molecular Biology in Prokaryotes · DNA structure and synthesis · PCR · Plasmids and l · Mechanism of gene expression · Regulation of gene expression · Principles of genetic manipulation · Simple vectors · Constructing and screening simple libraries · Characterising and altering cloned DNA · Expression of foreign proteins in Escherichia coli · More complex libraries and their screening PART II (2½ days) Genes and Gene Expression in Complex Organisms · Eukaryotic genome organisation · Vectors and plasmids for eukaryotic cells · Analysing complex genomes and mapping · Eukaryotic gene expression · Eukaryotic gene regulation · Isolating genes from complex genomes · Expressing cloned DNA in eukaryotic systems · Diagnostics and gene therapy · Transgenic plants · Transgenic animals · Heterologous gene expression
	Organized by:	University of Oxford’s Department for Continuing Education
	Invited Speakers:	Dr Diljeet Athwal is a Senior Research Scientist in Immunology at Celltech, one of Europe’s leading biotechnology companies. His interests are in protein engineering and the production and therapeutic application of humanised monoclonal antibodies in human disease. Dr Mick Coleman is a postdoctoral research scientist in the University of Oxford’s Department of Pharmacology. His research interests are the identification of a gene in the mouse which influences the degeneration of damaged axons. Professor Keith Dyke is a University Lecturer in Microbiology in the University of Oxford’s Department of Biochemistry and Fellow of Wadham College, with a particular interest in the molecular biology of resistance to antibiotics in staphylococci. Professor Christopher Leaver F.R.S, F.R.S.E is Sibthorpian Professor of Plant Science and Head of Department of Plant Sciences. His research interests concern the molecular, biochemical and cellular basis of plant development and the regulation of metabolism in plants. He has a strong interest in biotechnological exploitation of the plant sciences. Dr Chris Norbury (Course Director Part II) is Head of the Cell Cycle Group in the Imperial Cancer Research Fund Laboratories working in the University of Oxford’s Institute of Molecular Medicine. Prior to this he carried out postdoctoral studies on eukaryotic cell cycle control in the Microbiology Unit at the University of Oxford under Professor Paul Nurse. Dr Judith Skinner is a senior research associate in the Genetics Unit of the University of Oxford’s Department of Biochemistry. Her research interests include transgenics and developmental biology. Professor Michael Yudkin (Course Director Part I) is a University Lecturer in the University of Oxford’s Department of Biochemistry and Fellow of Kellogg College, with a particular interest in the transcriptional regulation of spore formation in Bacillus. Co-author of Comprehensible Biochemistry (Longman).
	Deadline for Abstracts:	N/A
	Registration:	REGISTRATION FORM Please register the following delegate for the course named below (for multiple registrations please use copies of theis form): Course Name_____________________________________________________ Date of Course _________________Registration Fee________________________________ Title (Dr/Mr/Ms etc)_________________________________________________________ Family Name/Surname_______________________________________________________ First Name___________________________________________________________________ Position/Job Title________________________________________________________________ Organisation____________________________________________________________________ Full Mailing Address ________________________________________________________ _______________________________________________________________________ ______________Post code______________Telephone____________Fax_____________ Email _____________________ Signature_________________________________ Name and Position of person authorising the booking ______________________________________________ Total amount payable_______________ ( )I enclose a cheque made payable to OUDCE in £ Sterling ( )I enclose a purchase order authorisation ( )I wish to pay by Bank Transfer, please send the details ( )Please debit by VISA ( )ACCESS ( )MASTERCARD( ) Card Number _ _ _ _ _ _ _ _ _ _ _ _ _ Expriry Date _ _ _ _ _ _ Card Holders Address:__________________________________________________ Special Requirements (diet, disability etc):_________________________________________ Background: It is helpful for the course tutors to know the background of delegates; please could you provide the details listed below. · Your main discipline (e.g. Biochemistry, Organic Chemistry, Molecular Biology, Pharmacology etc.) __________________________________________________________ · Your background (please circle) BSc/MSc/MD/PhD PLEASE RETURN THIS COMPLETED FORM TO RACHEL BRISTOW: University of Oxford, CPD Centre 67 St Giles Oxford OX1 3LU or Fax the form to (+44) (0) 1865 288163 REGISTRATION TERMS AND CONDITIONS Places are limited so early registration by application form is strongly recommended. This will assure a place on the conference. Registration by Fax or Mail: Upon request, a place on the conference can be reserved for individuals who require time to obtain authorisation and process the payment of fees. This can be done by faxing or mailing the completed and signed application form to Rachel Bristow (Fax No: +44 (0)1865 288163). Invoices will be issued immediately to those submitting application forms only. Please note that enrolments are made on a strictly first-come first-served basis, and therefore bookings will only be confirmed after a completed application form has been received. Note also that the organisers reserve the right to refuse admission to any delegate who has not paid the registration in full before the conference starts. In the event of late bookings, payment in full will be required at the registration on the first day of the conference or it is our policy to request credit card details which will be held for three weeks before processing or until payment is received. Those who register by mail and have not received confirmation within three weeks should call us to ensure that their application has not been mislaid. Any delegate who has not received a confirmation of registration five days prior to the scheduled date of a conference should ring the CPD Centre to confirm that the conference will convene as scheduled. REGISTRATION FEES The full conference fee covers tuition, notes, lunches and daytime refreshments. PAYMENT: Payment can be made in several ways: By cheque: payable to the OUDCE in pounds sterling. By credit card: using VISA, ACCESS or MASTERCARD. We are not able to accept any other forms of credit card. By Bank Transfer: please inform us and we will send the appropriate details. REFUND POLICY This Programme is financially self-supporting, and it is necessary to establish a minimum enrolment in each conference. If the conference is cancelled by the organisers, registered delegates will be given as much notice as possible (normally at least 10 days prior to the conference start-date). However, our liability will be limited to the refund of the registration fees in full (without deductions). If a registration is cancelled by a delegate, full refunds of registration fees less £50 administration costs are payable for cancellations received in writing ten working days before the conference starts. After this date no fees are returnable. The organisers reserve the right to make alterations to the stated Programme and other arrangements as deemed necessary. SUBSTITUTIONS Registered delegates who cannot attend the conference may be substituted at any time. Please notify Rachel Bristow at the address given below as far in advance as possible, giving full details of the person who will attend in your place. A completed application form for the replacement should thereafter be faxed to the CPD Centre. FURTHER INFORMATION: Queries about any aspects of the programme - including registration, accommodation, fees, etc. - should be referred to either: Rachel Bristow, CPD Administrative Assistant, E-mail: rachel.bristow@conted.ox.ac.uk, Tel: +44 (0)1865 288162 Suzy Hodge, CPD Portfolio Manager E-mail: suzy.hodge@conted.ox.ac.uk, Tel: +44 (0)1865 288167 Fax: +44 (0)1865 288163 PLEASE RETURN THE REGISTRATION FORM TO RACHEL BRISTOW: University of Oxford, CPD Centre 67 St Giles Oxford OX1 3LU or Fax the completed form to the number above
	Email for Requests and Registration:	cpdbio@contend.ox.ac.uk
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