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To: list@hum-molgen.de
Subject: HUM-MOLGEN News Alert - January 25, 2005
From: FS Zollmann <zollmann@hum-molgen.de>
Date: Tue, 25 Jan 2005 13:58:02 +0100

___________________________________________________________________________

SiRNA Strategies
6-7 April 2005, Café Royal, London
Effective Target Validation, In Vivo and Therapeutic Applications
http://hum-molgen.org/cgi-bin/banner1/ads.pl?banner=2005-informa3

High-Level Discussion Platform for Sharing Experimental Knowledge
___________________________________________________________________________


INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS
HUM-MOLGEN News Alert - January 25, 2005 - http://hum-molgen.org


DIAGnostics - Clinical Research (professional requests)
http://hum-molgen.org/clinical-research/

- Genetic Association Database-Expertsdb
   http://hum-molgen.org/bb/Forum2/HTML/000173.html

- Post diagnostic request / call for collaboration
   http://hum-molgen.org/diagnostic-posting or
   contact admin@hum-molgen.org


Genetic News
by T.M. D'Souza, F.S. Zollmann
http://hum-molgen.org/NewsGen

- Call for Assistant News Editors
   Join our editorial team
   http://hum-molgen.org/NewsGen/04-2003/msg01.html

- Hearing Anger In Voices
   Study suggests that the sound of anger enhances the brain's response to
   voices.
   http://hum-molgen.org/NewsGen/01-2005/msg33.html

- Understanding Cocaine Cravings
   Cocaine cravings following an extended withdrawal require the activation
   of a protein called extracellular-signal regulated kinase (ERK) in a
   part of the brain involved in motivation and emotion.
   http://hum-molgen.org/NewsGen/01-2005/msg32.html

- Tagging Strategy Makes It Easier For Researchers To Leave Their Mark
   New method for the quick addition of small labeling molecules promises
   to simplify studies tracking the localization and dynamics of
   cell-surface proteins without interfering with cellular function.
   http://hum-molgen.org/NewsGen/01-2005/msg31.html

- Stem Cells In Need Of A Fresh Start
   Report indicates that a foreign molecule present in human embryonic stem
   cells (HESCs) may lead to their being killed by the immune system if
   they are used in a transplantation setting.
   http://hum-molgen.org/NewsGen/01-2005/msg30.html

- Reproductive ACE
   A protein that controls blood pressure is also crucial for
   fertilization.
   http://hum-molgen.org/NewsGen/01-2005/msg29.html

- Viagra For A Broken Heart
   Sildenafil, better known as Viagra, can prevent and reverse the
   pathological growth of the heart.
   http://hum-molgen.org/NewsGen/01-2005/msg28.html

- Muscle-Driven Microrobots
   Scientists show that it is now possible to start with single cells on
   silicon chips and obtain micromechanical devices operated by muscle
   tissue.
   http://hum-molgen.org/NewsGen/01-2005/msg27.html

- Natural Selection In Humans
   Report describes evidence for natural selection acting on the human
   genome.
   http://hum-molgen.org/NewsGen/01-2005/msg26.html

- Stimulating Insight Into Reproductive Hormones
   The revelation, how follicle-stimulating hormone (FSH) binds to its
   receptor on the cell surface, may provide scientists with the key for
   aiding future drug discovery efforts.
   http://hum-molgen.org/NewsGen/01-2005/msg25.html

- Understanding The Brain, One Cell At A Time
   Scientists report on a tool that can capture the activity of neuronal
   populations at single-cell resolution and up to four times deeper into
   the brain than before.
   http://hum-molgen.org/NewsGen/01-2005/msg24.html

- Pokemon Protein Puts New Cancer Treatment On The Cards
   Scientists uncover the role of Pokemon, a key protein in cancer
   progression.
   http://hum-molgen.org/NewsGen/01-2005/msg23.html

- Protein's Role In Immune Defence Uncovered
   Researchers uncover the role of a vital protein called IRF-5 in
   triggering immune defences against invading pathogens.
   http://hum-molgen.org/NewsGen/01-2005/msg22.html

- Scientists Discover Key Genetic Factor in Determining HIV/AIDS Risk
   Individual risk of acquiring HIV and experiencing rapid disease
   progression is not uniform within populations
   http://hum-molgen.org/NewsGen/01-2005/msg21.html

- Researchers simulate molecular biological clock
   Stochastic simulation of the mammalian circadian clock.
   http://hum-molgen.org/NewsGen/01-2005/msg20.html

- Thinking small: Texas A&M team creates lab-on-a-chip
   On-chip manipulation of levitated femtodroplets
   http://hum-molgen.org/NewsGen/01-2005/msg19.html

- Study finds more than one-third of human genome regulated by RNA
   Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that
   Thousands of Human Genes are MicroRNA Targets
   http://hum-molgen.org/NewsGen/01-2005/msg18.html

- Found: Missing sequence of the human Y chromosome
   Sequence may contain genes controlling stature and tumor development
   http://hum-molgen.org/NewsGen/01-2005/msg17.html

- COX-2 levels are elevated in smokers
   Tobacco smoke triggers the production of COX-2, a cellular protein
   linked to the development and progression of cancer
   http://hum-molgen.org/NewsGen/01-2005/msg16.html

- Research Identifies Promising Route for Treating Age-Related Hearing
   Loss
   Proliferation of Functional Hair Cells in Vivo in the Absence of the
   Retinoblastoma Protein
   http://hum-molgen.org/NewsGen/01-2005/msg15.html

- First 'atlas' of key brain genes could speed research on cancer,
   neurological diseases
   Mouse brain organization revealed through direct genome-scale TF
   expression analysis
   http://hum-molgen.org/NewsGen/01-2005/msg14.html

- Transistor Genetics
   Self-assembled carbon-nanotube-based field-effect transistors
   http://hum-molgen.org/NewsGen/01-2005/msg13.html

- Mouse brain tumors mimic those in human genetic disorder
   Natural history of neurofibromatosis 1-associated optic nerve glioma
   formation in mice
   http://hum-molgen.org/NewsGen/01-2005/msg12.html

- Humans Are A 'Privileged' Evolutionary Lineage
   Accelerated evolution of nervous system genes in the origin of Homo
   sapiens
   http://hum-molgen.org/NewsGen/01-2005/msg11.html

- Growth of common skin cancer blocked in gene-switch mice
   Scientists have identified genes that promote the growth and recurrence
   of skin cancer
   http://hum-molgen.org/NewsGen/01-2005/msg10.html

- Contact Genetic News editors
   news@hum-molgen.org


Literature
http://hum-molgen.org/literature/

- International Journal of Biological Sciences
   is a new peer-reviewed   journal publishing scientific papers
   of significance in all areas of biological sciences
   http://hum-molgen.org/literature/01-2005/msg01.html


Biotechnical requests and sources
http://hum-molgen.org/biotechnology


Biomedical Positions
http://hum-molgen.org/positions/

- Biochemistry / Immunology: Pre doctoral fellow
   University of Lleida, Lleida, 25008, Spain
   http://hum-molgen.org/positions/predoctoral/0522.html

- Computational Genetics / Bioinformatics: Chargé de Recherche 2ème classe
    in Functional Genomics & Human Nutrition
   INRA, Saint-Genes Champanelle, 63000, France
   http://hum-molgen.org/positions/postdocs/2541.html

- Medical Research (others): Postdoctoral Appointee (Grant Funded)
   UMDNJ, PISCATAWAY, 08854
   http://hum-molgen.org/positions/predoctoral/0523.html

- Medical Research (others): Postdoctoral Fellow
   UMDNJ, NEW BRUNSWICK, 08901
   http://hum-molgen.org/positions/academic_positions/0186.html

- Medical Research (others): Clinical Studies Manager - 290626-North
   Wales, PA
   ICON Clinical Research, Inc., NASHVILLE, 37501, USA
   http://hum-molgen.org/positions/non_academic_positions/1637.html

- Medical Research (others): Research Teaching Specialist III (Grant
   Funded)
   UMDNJ - UNIV OF MED & DENTISTRY OF NJ, NEW BRUNSWICK, 08901
   http://hum-molgen.org/positions/academic_positions/0184.html

- Medical Research (others): Principal Investigator on Biomedical
   Engineering
   Shanghai Institute of Biomedical Engineering, Boston, MA 02118, USA
   http://hum-molgen.org/positions/academic_positions/0187.html

- Medical Research (others): Research Teaching Specialist IV (Part time,
   Grant Funded)
   UMDNJ, PISCATAWAY, 08854, USA
   http://hum-molgen.org/positions/academic_positions/0188.html

- Medical Research (others): Postdoctoral Appointee (Grant Funded)
   UMDNJ, NEW BRUNSWICK, 08901
   http://hum-molgen.org/positions/postdocs/2543.html

- Medical Research (others): Contract Associate/Analyst - North Wales, PA
   290567
   ICON Clinical Research, Inc., NEW BRUNSWICK, 08901
   http://hum-molgen.org/positions/non_academic_positions/1639.html

- Medical Research (others): Graduate Student (Grant Funded)
   UMDNJ, PISCATAWAY, 08854
   http://hum-molgen.org/positions/academic_positions/0185.html

- Medical Research (others): Medical Technologist - Johnson, AR
   Labcorp, Johnson, 72741
   http://hum-molgen.org/positions/academic_positions/0183.html

- Medical Research (others): Clinical Research Assistant - 290353
   ICON Clinical Research, Inc., WILMINGTON, 19801, USA
   http://hum-molgen.org/positions/non_academic_positions/1640.html

- Medical Research (others): Associate Director, Clinical Operations -
   North Wales, PA 2900052
   ICON Clinical Research, Inc., North Wales, 19436, USA
   http://hum-molgen.org/positions/non_academic_positions/1638.html

- Neurology / Neuroscience: Post doctoral position: Genetic analysis of
   complex lipid function in C. elegans
   MRC Laboratory for Molecular Cell Biology, London
   http://hum-molgen.org/positions/postdocs/2544.html

- Others: Bio Marketing and Sales Manager
   Hess Associates, Toronto, Ontario, M3B 3K4, Canada
   http://hum-molgen.org/positions/non_academic_positions/1636.html

- Pathology: Pathologist
   McGill University, Montreal, H3T1E1, Canada
   http://hum-molgen.org/positions/postdocs/2542.html

- Write a position announcement (free)
   1) Set up account: http://hum-molgen.de/cgi-bin/positions.pl?register
   2) Post position(s): http://hum-molgen.de/cgi-bin/positions.pl?login


Events in bioscience and medicine
http://hum-molgen.org/meetings/

- Post event
   http://hum-molgen.de/cgi-bin/meetings.pl?login


Registry of Biomedical Companies (954 active entries)
http://hum-molgen.org/companies/


Mailing List Administration (Join or leave the list)
http://hum-molgen.org/subscribe-na/


Feedback
contact admin@hum-molgen.org


Advertise at HUM-MOLGEN
contact FS Zollmann (dialogue@hum-molgen.org)


___________________________________________________________________________

SiRNA Strategies
6-7 April 2005, Café Royal, London
Effective Target Validation, In Vivo and Therapeutic Applications
http://hum-molgen.org/cgi-bin/banner1/ads.pl?banner=2005-informa3

High-Level Discussion Platform for Sharing Experimental Knowledge

The siRNA Strategies conference will stimulate new thoughts and ideas
in the RNAi field, offering you an opportunity to hear innovative
information and the latest updates. Companies who are applying RNAi
will present case studies on the practical approaches and effective
uses that are occurring, and are not always shared.

Knowledge will be pooled and ideas investigated through focused
discussion topics:

• What approach to take to target validation?
• Establishing the true impact of off-target effects
• Unravelling the different pathways
• What can delivery systems achieve?
• What are the pros and cons of different chemical modification?
• Addressing pharmacokinetics and modification issues for each disease
• What do I need for clinical testing of an siRNA compound?

___________________________________________________________________________



-- 
| INTERNATIONAL COMMUNICATION FORUM IN HUMAN MOLECULAR GENETICS
| HUM-MOLGEN - http://hum-molgen.org
| (C) 1994-2005 





   
 
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