HUM-MOLGEN archive: DIAG: 3 messages

************************************************************** HUM-MOLGEN DIAGnostics/Clinical Research ************************************************************** This DIAG message contains 3 submessage(s): 1) Prostate cancer family/reply 2) Chromosomal translocations/reply addendum 3) Note to people who previously posted inside DIAG Carlo Gambacorti MD, Editor, Human Molecular Genetics network Diagnostics/Clinical Research Section ************************************************************** ************************************************************** >[We are currently working with a family with numerous members with >prostate cancer spanning three generations. They (and we) are highly >motivated to pursue linkage analysis. Are there any groups interested >in helping with this project? Contributing other families? Ideas? > >Jose A Bufill MD >Hereditary Cancer Program >Elkhart Clinic >Elkhart, IN, USA >jabufill@skyenet.net] > We are looking at mutations in a gene which may be involved in familial prostate cancer..would you be interested in a collaboration that would allow us to quickly scan your proband for mutations. John C. Law, Ph.D. Department of Human Genetics University of Pittsburgh Pittsburgh, PA 15261 law@hoffman.mgen.pitt.edu ************************************************************** ************************************************************** Date sent: 3-JAN-1996 09:05:04 > >Where can I find a catalogue of described chromosome translocations? > > >COLD SPRING HARBOR LABORATORY >1 Bungtown Road >Cold Spring Harbor, NY 11724 -------------------------------------------------- (largely contributed by Martin Kennedy) For cancer the definitive source is Mitelman's (4th ed - though may be a more recent edition) "Catalog of chromosome aberrations in cancer", 1991, Wiley Liss ISBN 0-471-56087-1 The hard-copy Human Gene Mapping publications have tables of translocations; the last one we have is HGM 11 (1991). Cytogenet. Cell Genet. 58:1-2200. I think there may have been one more book publication, but I believe that the electronic version (GDB - see below) is now the exclusive repository of this information. Also a review on CT was published in Nature, 372, 143-149, 1994. Alternatively, try the following online sources: -------------------------------------------------- CAD The Chromosome Abnormality Database (CAD) stores records of human chromosome abnormalities, and can be freely searched. Established in early 1991, the CAD contains records of acquired and constitutional chromosome abnormalities from cytogenetics laboratories throughout the United Kingdom. The database includes information on the availability of cell lines and other stored material. WWW: http://www.hgmp.mrc.ac.uk/local-data/Cad_Preamble.html Gopher: gopher.hgmp.mrc.ac.uk (go to "HGMP Databases/" directory). ---------------------------------------------------------- GDB (Genome Database) A comprehensive, fully searchable repository of human gene mapping information, cross referenced to other relevant databases including OMIM and the Genome Sequence Data Bank. May be worth searching for info on specific translocations. WWW: http://gdbwww.gdb.org/gdbhome.html Gopher: gopher.gdb.org (in "Search Databases at Hopkins" directory) E-mail server: mailserv@gdb.org Anonymous ftp: ftp://ftp.gdb.org/ ---------------------------------------------------------- OMIM (Online Mendelian Inheritance in Man) Subtitled "A catalog of human genes and genetic disorders", this is the electronic form of Victor McKusick's extraordinary compilation, Mendelian Inheritance in Man (McKusick, 1994; Pearson et al., 1994). It contains a wealth of data on human genetic traits and inheritance patterns, and each disease entry consists of a comprehensive literature review with full cross referencing to other relevant databases. WWW: http://gdbwww.gdb.org/gdbhome.html Gopher: gopher.gdb.org (in "Search Databases at Hopkins" directory) E-mail server: mailserv@gdb.org ************************************************************** ************************************************************** NOTE TO PEOPLE WHO PREVIOUSLY POSTED REQUESTS INSIDE DIAG A survey is being conducted on the average feedback DIAG messages receive. If you posted a message inside DIAG in the last year, please provide us this information: - subject of the posting; - # of replies received; - whether the replies you received were (or not [higher or lower ?]) in the range you expected. Thank you for your collaboration ! **************************************************************