HUM-MOLGEN archive: NEWS: in Bioscience and Medicine

************************************************************** HUM-MOLGEN News in Bioscience and Medicine ************************************************************** News in Bioscience and Medicine: http://www.informatik.uni-rostock.de/HUM-MOLGEN/NewsGen/ HUM-MOLGEN WWW: http://www.informatik.uni-rostock.de/HUM-MOLGEN/ Summary (postings by chronological order): ------------------------------------------ 1 | The Hybridoma Data Bank 2 | Cystic Fibrosis Mutation Data Base Online 3 | THE GENETIC DISEASE MAILING LIST 4 | A new web site "Biology of the Mammary Gland Database" was established. 5 | The home page of the Association for Glycogen Storage Disease 6 | Mouse/Human Dysmorphology Database 7 | REBPAGE - the brain in health and disease 8 | How to announce new Internet resources, press releases etc. (free) -------------------------------------------------------------------- 1 | The Hybridoma Data Bank | WWW: http://www.atcc.org/hdb/hdb.html is now available for searching via the web. If you are searching for a mab against a specific antigen, this resource is designed just for this task. Distributor information is also included to help locate and obtain a mab or cell line. -------------------------------------------------------------------- 2 | Cystic Fibrosis Mutation Data Base Online | WWW: http://www.genet.sickkids.on.ca/CFMDB.html | E-mail: cfdata@sickkids.on.ca The information contained in this database is compiled with information collected by the Cystic Fibrosis Genetic Analysis Consortium. Use of information in this database is subject to the guidelines of the CF Genetic Analysis Consortium. CFTR Mutation Data Base CFTR sequence polymorphisms Exon/coding regions Intron/non-coding regions CFTR Gene Sequence CFTR cDNA Sequence Reference Newsletters For further information, please contact: Lap-Chee Tsui Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, CANADA. Telephone: +1 (416) 813-6015; Fax: +1 (416) 813-4931; -------------------------------------------------------------------- 3 | THE GENETIC DISEASE MAILING LIST | WWW: http://q.continuum.net/~wrosen/list.html | E-mail: wrosen@q.continuum.net This list is a means of networking and communication for individuals concerned with the various genetically-transmitted diseases affecting Jewish populations. Everyone is invited to subscribe, because diseases common among Jewish people may affect individuals from any cultural or ethnic group. Anonymous subscriptions are not permitted. A verifiable personal name must be provided to remain a subscriber to this list. However, the subscriber list is not available publicly. The following diseases are thought to occur at an increased frequency, although not necessarily exclusively, among Jewish populations: Tay-Sachs Disease, Gaucher Disease , Essential Pentosuria, Familial Dysautonomia, Factor XI Deficiency, Canavan Disease, Torsion Dystonia, Abetalipoproteinemia, Bloom's Syndrome, Niemann-Pick (A+B) Disease, Cohen's Syndrome, Cystic Fibrosis, B-thalassemia, Bronchiectasis, Mucolipidosis IV Press reports have suggested that many breast and ovarian cancers have a genetic link within the Ashkenazi Jewish population. This summary of recent findings provides a detailed discussion of the issue. To subscribe, go to the subscription form at http://shamash.nysernet.org/listform.html and select genetic-disease. -------------------------------------------------------------------- 4 | A new web site "Biology of the Mammary Gland Database" was established. | WWW: http://alice.dcrt.nih.gov/~mammary/ | E-mail: mammary@nih.gov This Web site serves as a forum to integrate various aspects of Mammary Gland Biology, to promote collaborations and the exchange of ideas, knowledge and resources. It was established in October of 1995 by the Section of Developmental Biology at the National Institutes of Diabetes, Digestive and Kidney Diseases within the National Institutes of Health,Bethesda, Maryland, USA. What's Here: Mammary Gland Database Bulletin Board Development (includes transgenic and null mice with a mammary phenotype) mini reviews Genetics Gene Regulation Biotechnology Milk Tools (features technologies and reagents) Research Groups Literature Art and History Related Web sites Note This Web site contains information not yet published in Journals or books. Our philosophy regarding data submission and distribution is outlined in the Mammary Gland Information Core (Magic) page -------------------------------------------------------------------- 5 | The home page of the Association for Glycogen Storage Disease | WWW: http://www.compulink.co.uk/~embra/agsdhome.html | E-mail: odonnell@sasa.gov.uk The home page of the Association for Glycogen Storage Disease (UK) contains information about the different types of GSD, as well as information about the AGSD's activities - conferences, publications research targets etc. Although the information is intended to be understandable by affected families, it is hoped that professionals will also find it useful. Feedback and suggestions for more material are welcome. -------------------------------------------------------------------- 6 | Mouse/Human Dysmorphology Database | WWW: http://www.hgmp.mrc.ac.uk/DHMHD/dysmorph.html | E-mail: rwinter@ich.bpmf.ac.uk This application consists of three separate databases of human and mouse malformation syndromes together with a database of mouse/human syntenic regions. The mouse and human malformation databases are linked together through the chromosome synteny database. The purpose of the system is to allow retrieval of syndromes according to detailed phenotypic descriptions and to be able to carry out homology searches for the purpose of gene mapping. Thus the database can be used to search for human or mouse malformation syndromes in different ways:- - By specifying specific malformations or clinical features, or chromosome locations. - By Homology. - By asking for human syndromes located at a chromosome region syntenic with a specific mouse chromosome region (and vice versa from human to mouse). The databases in the system are derived from different sources and authors. These are:- a) The London Dysmorphology Database (LDDB). This is a database of over 2000 non-chromosomal malformation syndromes. Each syndrome is classified according to a master list of phenotypic features. The full database is microcomputer based and is published by Oxford University Press (Winter RM, Baraitser M (1993). The London Dysmorphology Database: Oxford University Press, Oxford.). It contains comprehensive data for each syndrome including literature references, a detailed abstract and clinical photographs stored on CDROM. In the present application a subset of around 50 per cent of the syndromes has been chosen. This is because many of the entries on the full database refer to single case reports or families which are important to register for clinical diagnostic purposes but which are not yet useful for gene mapping purposes. The syndromes are classified according to a master list of clinical features. This list is a subset of the full LDDB clinical feature list containing the major malformations or physical abnormalities. The clinical features of each syndrome are given together with hypertext links to OMIM -- Online Mendelian Inheritance in Man (which is integrated with The Genome Data Base. Where a syndrome does not have an OMIM entry, a key reference is provided (currently not available). b) Mouse malformation database. This is an updated database of mouse malformation syndromes developed with the same system for phenotypic description used in LDDB (Winter RM. A mouse malformation mutant supplement to the London Dysmorphology Database. Am J Med Genet. 30:819-812;1988). Hypertext links to mouse databases at other centres are provided, more specifically: The Mouse Genome Database (MGD), which incorporates: The Encyclopedia of the Mouse Genome The Mouse Locus Catalog c) Human Cytogenetic Aberrations. This a database of the clinical effects of human chromosomal aberrations (Schinzel A. Cytogenetics Database: Oxford Medical Databases: 1994). The data used in the current application is a subset containing the clinical features of all aberrations that have been reported more than once. d) Mouse/Human chromosome homology. This is derived from a database kept by Dr Tony Searle (Searle AG, Edwards JH, Hall JG. Mouse homologues of human hereditary disease. J Med Genet 31:1-19, 1994). -------------------------------------------------------------------- 7 | REBPAGE - the brain in health and disease | WWW: http://www.uni-hohenheim.de/~rebhan/rp.html | E-mail: rebhan@uni-hohenheim.de This site offers a news section with selected articles about brain disorders (treatment, diagnosis, basic research), an extensive web guide that links you directly to databases, discussions, meeting informations, etc., and many other services that may be of interest for people searching information about any brain disorder. -------------------------------------------------------------------- 8 | How to announce new Internet resources, press releases etc. You can announce (free) new Internet resources, press releases etc. at http://www.informatik.uni-rostock.de/HMB-NewsGen/vw3news?postF For other announcements please take a look at http://www.informatik.uni-rostock.de/HUM-MOLGEN/hum/submit.html **************************************************************