HUM-MOLGEN archive: DIAG: del 9p21 in pediatric ALL, CF in chinese patients

************************************************************** HUM-MOLGEN DIAGnostics/Clinical Research ************************************************************** This DIAG message contains 2 submessage(s): 1) Chromosome 9p21 in Acute Lymphoblastic Leukemia 2) CF in chinese patients Carlo Gambacorti MD, Editor, Human Molecular Genetics network Diagnostics/Clinical Research Section ************************************************************** ************************************************************** We are currently treating a 2 yr female with ALL and a 9p21 deletion. We understand the cytogenetics abnormality confers a very poor prognosis. In fact she relapsed 26 weeks into treatment and fortunately she is now in second remission. Has anybody had any patient with this chromosomal abnormality? Dr Reg Lam-Po-Tang Dept of Haematology and Cytogenetics Prince of Wales and Prince of Wales Children Hospitals Ph 61-2-697 8201 or 61- 018 863 350 Fax 61-2-398 9976 or 313 8112 R.Lam@UNSW.EDU.AU ************************************************************** I would like to know if CF has ever been reported in Chinese patients. Also, now that mutations of CFTR have been reported without clinical CF, does anyone know how often these mutations are seen in non-Caucasians? From: Agnes Tay <mcbtayhn@LEONIS.NUS.SG>