CALL: gene therapy, chr 12q13, and Simpson

[Arthur Bergen <bergen@AMC.UVA.NL>]

Note from the editor:

This CALL message contains three submessages:

1) CALL for collaboration in somatic gene therapy

2) CALL for markers on chromosome 12q13

3) additional replies on the CALL about the Simpson case


The CALL TOPIC is open for FREE CALLS for assistance or offering of
help in the field of Human Genetics. Please state and specify your
CALL as precisely as possible, and include your name and E-mail adress
at the bottom of the message.

Good CALLS ;-)

Arthur Bergen


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From: EXMOND DECRUZ <EDECRUZ@WIS.RIV.CSU.EDU.AU>
Subject: Gene Therapy Researchers


Dear HUM-MOLGENeticists,
I am interested in contacting researchers involved in the development
of somatic gene therapies.  I am working in the area of cancer gene
therapy but would like to hear from just about anyone involved in
trialling therapies involving genes at the  clinical, animal or in
vitro stage.
*******************************************************************


Date: Tue, 11 Apr 1995 15:50:41 -0700
From: DAOUST martin <daoustm@ERE.UMONTREAL.CA>
Subject: markers

To everybody,

I am looking for makers of any kind (VNTR, CA, STS, etc.) near the aquaporin
gene on chromosome 12q13 region.  Any help will be appreciated.

Thank you

Martin Daoust

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REPLIES ON SIMPSON CASE:

From:   IN%"ed@yoda.bsd.uchicago.edu"  5-APR-1995 18:08:50.20
To:     IN%"bergen@AMC.UVA.NL"
CC:
Subj:   RE: CALL: RE: Simpson case and ADD

FYI - OMIM hasn't yet been updated to cover the reference, Cook, EH, Stein,
MA, Krasowski, MD, Cox, NJ, Olkon, DM, Kieffer, JE & Leventhal, BL. (1995)
Association of attention-deficit disorder and the dopamine transporter
gene," American Journal of Human Genetics 56:993-999.

Briefly, linkage disequilibrium was found between a VNTR in the 3' UTR of
SLC6A3 (dopamine transporter) and ADHD using haplotype-based relative risk.
Of course, independent replication is necessary.

Ed Cook, M.D.


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>
>ADDITIONAL REPLIES TO SIMPSON CASE:
>
>From:   IN%"'USA::MRGATE::'A1::AGOSTINO'
<AGOSTINO%USA.MRGATE.'A1.decnet@usav01.
>glaxo.com>"  5-APR-1995 17:23:16.56

>Subj:   RE: CALL: info wanted about Simpson case, and ADD
>
>From: <AGOSTINO%USA.MRGATE."A1.decnet@usav01.glaxo.com>
>From:   NAME: Mike Agostino
>        FUNC: Research Computing
>        TEL: 919-941-3532                     <AGOSTINO MJ@A1@USA>
>To:     NAME: WINS%"bergen@AMC.UVA.NL"
<WINS%"bergen@AMC.UVA.NL"@USA@MRGATE@USA>
>
>Regarding Attention Deficit Disorder, I found the following in OMIM (on the
>WWW:http://gdbwww.gdb.org/omimdoc/omimtop.html):
>
>143465 HYPERACTIVITY OF CHILDHOOD
>[ATTENTION DEFICIT-HYPERACTIVITY
>DISORDER; ADHD]
>
>TABLE OF CONTENTS
>
>       Text
>       References
>       Clinical Synopsis
>       Edit History
>
>TEXT
>
>Hyperactivity is a disorder of unknown cause that affects 2 to 4% of school-age
>children. Boys are affected about 8 times more frequently than girls.
Because of
>inability to demonstrate consistent neurobiologic differences between
>hyperactive children and normal controls, the validity of the hyperactivity
>syndrome remains controversial. By means of positron-emission tomography (PET)
>of the brain using (18F)-fluoro-2-deoxy-D-glucose, Zametkin et al. (1990) found
>that global cerebral glucose metabolism was 8.1% lower in adults with
>hyperactivity than in normal controls. Glucose metabolism was significantly
>reduced in 30 of 60 specific regions of the brain. Among the regions with
>greatest reduction were the premotor cortex and the superior prefrontal cortex.
>This study was done in adults because of ethical considerations about exposing
>children to a radioactive tracer; however, each of the 25 hyperactive
adults was
>the biologic parent of a hyperactive child. Biederman et al. (1990) reported
>that 28.6% of the biologic parents of hyperactive children also had a
history of
>hyperactivity. The parents in this
>study continued to have symptoms as adults.
>
>REFERENCES
>
>Biederman, J.; Faraone, S. V.; Keenan, K.; Knee, D. and Tsuang, M. T.:
>Family-genetic and psychosocial risk factors in DSM-III attention deficit
>disorder. J. Am. Acad. Child Adolesc. Psychiat. 29: 526-533, 1990.
>
>Zametkin, A. J.; Nordahl, T. E.; Gross, M.; King, A. C.; Semple, W. E.; Rumsey,
>J.; Hamburger, S. and Cohen, R. M.: Cerebral glucose metabolism in adults with
>hyperactivity of childhood
>onset. New Eng. J. Med. 323: 1361-1366, 1990.
>
>CLINICAL SYNOPSIS
>
>Neuro:
>              Hyperactivity.
>Misc:
>              Male:female ratio 8:1.
>Inheritance:
>              Autosomal dominant.
>
>EDIT HISTORY
>
>
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From:   IN%"rds@galactose.mc.duke.edu"  5-APR-1995 18:50:34.45
To:     IN%"bergen@AMC.UVA.NL"
CC:
Subj:   RE: CALL: info wanted about Simpson case, and ADD

My lab has been declared an OJ-Free Zone - a safe haven from media and
conversational bombardment ... I'm dying to give you details e.g. what I
overheard on "Hard Copy" last night.....

Rohan de Silva
Duke University Medical Center
Durham, NC