Rubany. Ylä-Herttuala. 2003. Human Gene Therapy: Current Opportunities and Future Trends.

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Book Info

Berlex Biosciences, Richmond, CA. Presents papers from the workshop, Human Gene Therapy: Current Opportunities and Future Trends, held in Berkeley, California, on October 2-4, 2002. Provides an overview of the present status and future directions of gene delivery systems and therapeutic strategies for gene therapy.

About this book

Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

Table of contents

G. Nabel: The Future of Gene Therapy;
S.Ylä-Herttuala: Angiogenesis Clinical Trials;
R.J. Samulski: AAV-Vectors, the Future Workhorse of Human Gene Therapy;
J.A.Wolff: Non-Viral Vectors for Cardiovascular Gene Delivery;
M. Watkins: Initial Clinical Results with Intra-Coronary Administration of AD5FGF-4 in Patients with Myocardial Ischemia;
G.Nabel: Caner Gene Therapy;
D.Kirn: Oncolytic Virotherapy as a Novel Treatment Platform for Cancer;
L.Seymour: Adenovirus Retargeting and Systemic Delivery;
H.Federoff: CNS Diseases Amenable to Gene Therapy;
G. Karpati: Molecular Therapies for the Nervous System and Muscle;
S.Kingsman: Lentivirus: A Vector for Nervous System Applications;
T. Asahara: Endothelial Progenitor Cells for Neovascularization;
B. Sullenger: Therapeutic Aptamers and Antidotes;
J.L. Nordstrom: Plasmid-Based Gene Transfer and Antiprogestin-Controllable Transgene Expression.